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Biomedical subjects

M Muñoz

Publications and source records attributed to M Muñoz.

At least 235 records · Page 13Linked to original sources
PubMed1982

[The Aicardi syndrome].

The authors present a case of a girl who showed flexion spasms, chorio-retinopathy and agenesis of corpus callosum, an association known as the Aicardi syndrome. They have made a wide revision of the literature, examining in detail the clinical aspects and diagnosis with other malformations and infections. Lastly, they comment the aspects of etiology and pathology of the disease which still remain unclear.

Abnormalities, Multiple↗
PubMed1981

Effect of a calcium inhibitor, nifedipine, on exercise tolerance in patients with angina pectoris: a double-blind study.

The effect of nifedipine on exercise tolerance was studied in 30 patients with stable angina and positive graded exercise testing. Treadmill exercise testing was performed on each of five consecutive days. Placebo or nifedipine, 10 mg sublingually, was given 30 minutes before exercise on the third day. The following day the intervention was reversed in a double-blind manner. Angina was abolished by nifedipine but not by placebo in 12 patients (40 percent). The time to onset of angina in the remaining patients increased from 4.1 +/- 0.4 (SEM) to 6.7 +/- 0.6 min (p less than .001). Time to ST depression greater than or equal to 2 mm increased from 4.0 +/- 0.3 to 5.4 +/- 0.5 min, while duration of exercise increased from 6.3 +/- 0.3 to 8.2 +/- 0.4 min (p less than .001). The maximum heart rate was 145 +/- 3.3 with nifedipine and 122 +/- 3.8 min-1 with placebo (p less than .01). Resting systolic blood pressure decreased 30 min after nifedipine administration from 131 +/- 3.4 to 106 +/- 2.9 mm Hg (p less than .01). Maximal systolic blood pressure during exercise was lower with nifedipine (127 +/- 4.8 mm Hg) than with placebo (155 +/- 5.6 mm Hg, p less than .01). We conclude that nifedipine significantly improves the exercise tolerance of patients with stable angina pectoris by decreasing peripheral vascular resistance and myocardial oxygen demand.

Adult↗
PubMed1980

A quantitative immunofluorescence test for the detection of anti-Candida antibodies.

A quantitative immunofluorescence assay for anti-Candida antibodies has been developed using a recently introduced system that includes an automatic fluorometer and a special immunoadsorbent for antigen coating. A commercially available cytoplasmic antigen preparation was adsorbed into the substrate, and after incubation with sera from patients with systemic candidiasis or from normal controls, the antibodies bound to the antigen-coated immunoadsorbent were revealed by the use of fluorescein-labeled antisera to human immunoglobulins. Using doubling dilutions of a high titer serum, a positive relation was found between antibody concentration and the logarithm of the intensity of fluorescence. Quantitative assays of unknown samples were performed using a calibration curve constructed from dilutions of that strongly positive sample; the results of antibody determinations were expressed as percentages of the control. Seven of 9 sera from patients with systemic candidiasis, and only 2 of 42 from asymptomatic individuals, had antibody levels considered significant in this assay. Precipitating antibodies were detected by counterimmunoelectrophoresis in all patients and in 18 of the asymptomatic controls; measurable antibody levels were also found in 14 controls showing no precipitating antibodies. This assay is simple, sensitive and inexpensive, and its quantitative nature makes it useful in the investigation of the immune response to C. albicans.

Antibodies, Fungal↗
PubMed1980

Pirifibrate in the treatment of hyperlipoproteinemias: a multicenter study.

Pirifibrate, a new hypolipemic substance, was studied in a multicenter trial for three months in 151 patients diagnosed as having type IIa, IIb or IV hyperlipoproteinemia (HLP). The patients admitted into the study had not received any hypolipemic medication for four weeks immediately before the study. We observed falls of between 24.3% and 20.0% in the average levels of plasma cholesterol in types IIa and IIb HLP. The triglycerides showed a decrease in average values, which varied between 31.0% and 38.6% in types IIb and IV HLP. The alpha-lipoproteins always increased in three types of HLP studied, while the pre-beta-lipoproteins showed a fall in averages in types IIb and IV HLP. The beta-lipoprotein levels were reduced in type IIa HLP and reached statistical significance.

Adult↗
PubMed1979

[Effect of intracerebroventricular injection of 6-hydroxydopamine and 5,6-dyhydroxytryptamine on the phasic secretion of luteinizing hormone (author's transl)].

In ovariectomized rats carrying an estradiol sylastic implant the effect of the intraventricular administration of the serotonin neurotoxin 5,6-dihydroxytryptamine and of the norepinephrine neurotoxin 6-hydroxydopamine on the circadian secretion of the luteinizing hormone (LH) was studied. The decrease of 5-HT after injection of 5,6-dihydroxytryptamine reduced the a.m. and p.m. values and suppressed the phasic rhythm of LH. The diminution of noradrenaline after administration of 6-hydroxydopamine increased the a.m. and did not alter the p.m. values, resulting in a partial abolition of the rhythm.

Animals↗
PubMed1975

Modification of synaptic efficiency, experiments in blatta orientalis.

The efficiency of synapt ic transmission in a nervous pathway--metathoracic ganglia from the cockroach--can be increased by various experimental situations, i.e., removal, immobilization or denervation of the forelegs of insects in ventral position. Leg immobilization with the insect in supine position by itself determines a minor increase which is not enhanced by removal or denervation of the forelegs. Under these conditions, the insects are able to hold their antennae with a midleg immediately after any of the leg treatments. On the other hand, if the insects are allowed to be in ventral position they can hold their antennae with a midleg only when they reach the ability to stand on the remaining three legs. During the time period needed to acquire this ability, the insects make repeated and spontaneous motor effects. The increase in synaptic efficiency observed and the achievement of the insect's ability to stand on three legs occur at about the same time. These observations suggest that the self-training determines the synaptic modifications which in turn could be related to the "learnt" behavioral reaction.

Animals↗