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Biomedical subjects

M Perrin

Publications and source records attributed to M Perrin.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Binding sites for growth hormone releasing factor on rat anterior pituitary cells.

Growth hormone releasing factors (GRFs) have been isolated from human pancreatic tumours (hGRF) and rat hypothalamus (rhGRF). The response to GRF at the pituitary level can be modulated by other factors, including glucocorticoids, thyroid hormones, somatostatin and other neuropeptides and somatomedins. Glucocorticoids enhance GRF-induced growth hormone (GH) secretion in primary cultures of rat anterior pituitary cells, and the synthetic glucocorticoid dexamethasone has recently been shown to increase the amounts of GH released in freely moving rats in response to submaximal doses of intravenous GRF. To investigate whether somatotroph sensitivity to GRF is modulated at its receptor level, we have developed a radioreceptor assay using an iodinated analogue of hGRF as radioligand. We report here that the relative binding affinities of rGRF, hGRF and the two analogues are correlated with their in vitro biological potencies. Further, the number of GRF binding sites is drastically decreased in cells deprived of glucocorticoids either in vivo or in vitro.

Adrenalectomy↗
PubMedDate not supplied

Oxford to Australia: symbiotic nursing relationship.

With the implementation of postregistration education and practice (UKCC, 1990) nurses are now looking forward to developing themselves personally and professionally. In order to facilitate this the John Radcliffe Hospital, Oxford, has set up observational visits to hospitals in Australia. This article describes one of these visits.

Australia↗
PubMedDate not supplied

[Results of reconstructive surgery in deep venous reflux at the subinguinal stage. Apropos of 93 interventions].

This study is a retrospective analysis of results of 93 interventions performed between 1984 and 1991 with an uniform indication: deep venous valvular reflux. Out of these 93 procedures, fifty (54%) have been undertaken in post-thrombotic syndrome (PTS), thirty-seven (40%) in deep primary vein incompetence (DPVI). Technically speaking, 46 valvuloplasties, 26 transplantations, 12 transpositions and 9 Psathakis procedures have been performed. Sixty one patients have a follow-up from 2 to 7 years (mean 44 months). In majority, valvuloplasties have been done in DPVI. Clinical and hemodynamic results in this group are good in 80% of patients controlled. Conversely transpositions, transplantations and Psathakis procedures have been undertaken essentially in PTS. Results obtained in this group are less satisfactory in terms of clinical findings and particularly in hemodynamics. Each group is analysed in details.

Adult↗
PubMedDate not supplied

[BNP/NT-proBNP: what is the best choice in an emergency laboratory?].

BNP and NT-proBNP are both well established as diagnostic and prognostic markers for congestive heart failure (CHF). However it remains for the biologist to choose between these two biomarkers depending on his equipment availability. The aim of this study was to compare results obtained with the Biosite Triage BNP assay and the Dade Behring NT-proBNP assay with regards to the clinical status. One hundred twelve patients (average age 76 +/- 13 years) with acute dyspnea were including and stratified by diagnosis at presentation into 3 groups: patients without acute CHF (group I, n=50), patients with non-cardiac dyspnea and CHF history (group II, n=22) and patients with acute CHF (group III, n=40). Levels of both BNP and NT-proBNP were higher among patients with cardiac dyspnea (group III) than among patients with a non-cardiac dyspnea (BNP=740 pg/mL versus 84 pg/mL; p<0.001 / NT-proBNP=7.502 pg/mL versus 499 pg/mL; p<0.001). ROC analysis for BNP or NT-proBNP were not statistically different in patients with acute CHF (group III) compared with patients with a non-cardiac dyspnea (group I + II) (AUC=0.927 versus AUC=0.930, p=0.90). Neither there was a difference between ROC analysis for BNP or NT-proBNP in patients with cardiac dyspnea (group III) compared to patients with a non cardiac dyspnea (group I) (AUC=0.981 versus AUC=0.975, p=0.76). Measurement of BNP or NT-proBNP is of identical interest for the diagnosis of acute CHF in acute dyspnea. The BNP Biosite assay was faster because analysis is performed on whole blood. With regards to analytical performance, the NT-proBNP Dade Behring assay had a higher accuracy and is highly recommended for the follow-up of CHF treatment.

Acute Disease↗
PubMedDate not supplied

[Valve repair at the level of the sub-inguinal deep venous plexus. Gadget technique or efficacious surgery?].

Between 1988 and 1990, the authors performed 35 valvuloplasties for major reflux syndrome involving the sub-inguinal deep venous system. Twenty two patients with a mean follow-up period of 23 months (1 year--3 years) were reviewed clinically and hemodynamically. Only one of the 10 patients with a chronic ulcer had developed a recurrence. This concerned the only postoperative thrombosis seen in this series. Results from a hemodynamic standpoint were as follows: Reflux evaluated preoperatively was Kistner type 4 with a popliteal venous reflux index (VRI) with a mean grade of 1.1. Postoperative evaluation (Duplex-Scan) showed the absence of reflux below the valvuloplasty in 86 p. cent of cases and VRI was normalised (less than 0.50) to the same extent. Mean venous filling time (PPG, peripheral pressure gradient measurement) after application of a supra-malleolar tourniquet was 8" (-8n + 4) preoperatively. It became normal in 13 patients and improved in 8 (mean of 82 p. cent). The results of valvuloplasty in this series confirm those published by other teams. They are notably superior to those offered by transposition and transplantation procedures. Unfortunately, this effective technique can only rarely be used in post-thrombotic syndromes and is useful essentially in Primary Deep Valve Insufficiency.

Adult↗
PubMedDate not supplied

[Surgery of the perforating veins in chronic venous diseases of the lower limbs].

After a brief anatomical reminder, the author discusses the place of surgery of the perforating veins in chronic venous deficiency, in three distinct aetiological and clinical circumstances: A first-hand prospective study of 220 successive operations for primary varices is analysed. In 14.5% of the cases, ligation of the perforators was associated with the stripping. In a retrospective analysis relating to 100 surgical reoperations on primary varices, the ligation of the perforators was associated with a different procedure in 13 of these patients. Finally, the author specifies the place of surgery of the perforators in the treatment of post-phlebitic syndrome. As regards the relapsing ulcer, 81% of the patients who had benefitted from this procedure never suffered relapsed ulcers (27 patients).

Chronic Disease↗