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Biomedical subjects

M W Roberts

Publications and source records attributed to M W Roberts.

At least 55 records · Page 3Linked to original sources
PubMed1985

Oral manifestations of the Rieger syndrome: report of case.

The Rieger syndrome is a rare, autosomal dominant disorder. It is characterized by defects of the anterior chamber of the eyes as well as developmental malformations of the dentition. A case is described that shows classic findings with emphasis on dental management. Oral abnormalities in the pedigree may also suggest subtle manifestations of the syndrome. Recognition of the dental anomalies may result in early diagnosis of the syndrome and prevent progressive visual loss.

Adult↗
PubMed1984

Occurrence of multiple dentigerous cysts in a patient with the Maroteaux-Lamy syndrome (mucopolysaccharidosis, type VI).

The mucopolysaccharidoses (MPS) are a group of genetic lysosomal storage diseases. These diseases result from a defect in specific lysosomal enzymes required for the degradation of specific mucopolysaccharides. These incompletely degraded saccharides accumulate in tissues and are excreted in the urine. A general characteristic of these diseases is dysostosis multiplex. Dental complications can be severe and include unerupted dentition, dentigerous cystlike follicles, malocclusions, condylar defects, and gingival hyperplasia. This report examines multiple dentigerous cysts in a patient with a deficiency in N-acetylgalactosamine-4-sulfatase, Maroteaux-Lamy syndrome (MPS VI). The inability to hydrolyze the sulfate group from N-acetylgalactosamine-4-sulfate residue of dermatan sulfate due to a deficiency in this enzyme results in the accumulation of dermatan sulfate in tissues and its excretion in the urine. Examination of dentigerous cyst fluid revealed glycosaminoglycan content of 397 microgram per milliliter. Compositional analyses revealed 60% hyaluronic acid, 30% chondroitin 4- and -6-sulfate, and only 10% dermatan sulfate. This was consistent with dentigerous cyst fluid derived from persons without mucopolysaccharide-storage disorders but distinctly different from glycosaminoglycans assayed from other body fluids of this patient.

Child, Preschool↗
PubMed1984

Dental root agenesis secondary to irradiation therapy in a case of rhabdomyosarcoma of the middle ear.

There have been only a few published reports on the dental-facial effects of radiation therapy and the subsequent oral management of these patients. A case involving a 13-year-old black male patient with a history of rhabdomyosarcoma is presented. The patient received 4,050 rads of radiation to the right middle ear when he was 2 years of age. His residual medical and dental difficulties are apparently complications from the initial therapy. Examination of the oral cavity revealed bimaxillary micrognathia and marked loss of vertical dimension. A Class II facial profile with Class I molar relationship was observed. The mandible was thin and hypoplastic, with a small knife-edge alveolar ridge. The remaining eighteen erupted permanent teeth were very mobile, and root development had ceased after only initial formation. All of the teeth except the first permanent molars were extracted, and immediate partial dentures were inserted at the time of surgery. A discussion of therapeutic considerations follows the case report.

Abnormalities, Radiation-Induced↗
PubMed1983

An analysis of the physical punishment component of a parent training program.

One component of a well-researched, standardized parent training program is to spank children for escape from time-out. The contribution of the spanking component to compliance acquisition in a clinic analog setting was evaluated. Time-out duration and child disruption at time-out release were balanced across spank and no-spank ("barrier") conditions. Sixteen noncompliant, clinic-referred pre-school children participated. The data indicated that both spank and barrier procedures were equally effective at increasing compliance ratios. Physical punishment did not appear to be a critical component. Given prior research, it was concluded that the enforcement of a minimum time-out duration is critical for compliance acquisition within the analog setting.

Behavior Therapy↗
PubMed1983

Comparison of morbillivirus proteins by limited proteolysis.

Proteins of a number of measles and SSPE virus strains have been compared by limited proteolysis and they appear to be largely conserved amongst the various strains. Viruses derived from SSPE cannot be distinguished from other measles viruses by this technique. Small differences in the digest patterns of the M proteins have been observed between the Edmonston and other measles virus strains. Furthermore, in some strains where the M proteins migrate slower in SDS-PAGE the limited proteolysis patterns are slightly different from those in other MV and SSPE virus strains. The limited proteolysis pattern of some canine distemper virus (CDV) proteins have been determined and nucleocapsid breakdown products have been identified in infected cells. Comparisons of proteins of four strains of CDV have shown that these, too, are largely conserved, although the digest of proteins of CDV appear to show more pronounced differences than those present in the MV and SSPE virus group. Limited proteolysis can be used readily to distinguish MV from CDV isolates.

Chemical Phenomena↗
PubMed1981

The effect of time-out release contingencies on changes in child noncompliance.

This project evaluated the effect of time-out release contingencies on changes in child noncompliance to maternal instructions. Twenty-four clinic-referred, non-compliant, preschool children served as subjects. Each child was assessed under baseline conditions and then under one of three experimental conditions: Parent Release, Child Release, or Control. Children in the Parent Release and Child Release conditions experienced time-out contingent upon noncompliance. Temporal and behavioral time-out release contingencies were present in the Parent Release condition but not in the Child Release condition. A spanking procedure was used to inhibit premature escape from time-out for children in Parent Release group. The results indicated that both time-out groups demonstrated increased compliance ratios. However, improvement associated with the Child Release condition was considered to be clinically insignificant.

Behavior Therapy↗
PubMed1981

A study of phosphorylation of the measles membrane protein.

A polypeptide (designated X) which migrates with a mobility similar to the membrane protein (M) of measles virus has been found in virus-infected cells. This polypeptide appears to be phosphorylated. However, limited proteolysis has shown that this protein is not a phosphorylated form of the M protein, but appears related to the P protein of measles virus.

Animals↗
PubMed1981

Double-stranded DNA antibodies: a comparison of four methods of detection.

Thirty-four antinuclear antibody (ANA) positive systemic lupus erythematosus (SLE) sera were tested for antibodies to double-stranded DNA (dsDNA) simultaneously using Farr, haemagglutination, Crithidia luciliae (CL) kinetoplast fluorescence and human metaphase chromosome fluorescence assays. Significant correlation (p less than 0 x 05) was found between the Farr and CL assays, with the two fluorescence tests (CL and metaphase) displaying the greatest degree of association (p = 0 x 00001). No correlation could be demonstrated between the haemagglutination test and any of the other three assays. Six hundred and ninety-one sera from patients with a range of provisional rheumatological diagnoses were prospectively analysed for dsDNA antibodies using Farr and metaphase assays. A correlation coefficient of 0 x 84 was obtained between the two assays. The metaphase assay provides comparable results to other more established assays, and because it is simple, reliable and sensitive, it should be seriously considered for routine use in testing for dsDNA antibodies.

Antibodies, Antinuclear↗
PubMed1980

Polypeptide synthesis i mumps virus-infected cells.

The synthesis of polypeptides in infected Vero cells has been studied with two tissue culture adapted strains of mumps virus. Minor differences between the strains are found in the mobilities of the virus-specific polypeptides in SDS-PAGE. Eight virus-induced polypeptides have been identified with mol. wt. of 180K, 80K, 71K, 69K, 45 K, 39K, 23K and 17K. These may correspond to the L, HN, N, Fo, P, M, C and S polypeptides identified in other paramyxoviruses. The 69K F0 glycoprotein is probably a precursor for glycopolypeptides F1 and F2 with mol. wt. 61K and 14K, respectively.

Animals↗
PubMed1978

The assessment of maladaptive parent-child interaction by direct observation: an analysis of methods.

Six direct observation technologies for assessing parent-child interactions are examined: Descriptive-narrative, event recording, three types of interval sampling, and sequential event recording. Selected articles in the clinical literature are reviewed to illustrate use of each technology. Furthermore, the yield of each procedure in terms of four assessment criteria was evaluated: precise description of the parent-child interaction, target selection, identification of the intervention strategy, and evaluation of the intervention technique. The sequential-event-recording technology was determined to be most advantageous in terms of the four criteria.

Adult↗
PubMed1978

Clinical evaluation of three acid-etch composite resin systems: two-year report.

One hundred fifty-seven fractured anterior teeth were restored with one of three acid-etch composite resin systems and were clinically and radiographically evaluated for 24 months. Of the three systems evaluated, the material activated by ultraviolet light provided the highest retention rate and clinical acceptance.

Acid Etching, Dental↗
PubMed1978

Nutrition and its importance in dental health.

Balanced and good nutrition is necessary for the growth, development, and maintenance of the dental and oral structures. Nutrition counseling is, therefore, of paramount importance. The physician who is aware of the factors that cause dental and oral disease will be in a position to intercept the progress of dental caries caused by an incorrect diet. This paper considers the significance of highly cariogenic foods, particularly sucrose, and the difficulties of removing it from the diet. A method of conducting a diet survey is presented. The importance of fluoridation is discussed, with elaboration of the advisable prescribing techniques for fluoride supplementation of the diet. Cooperation between physician and dentist is important in order to insure the prevention of dental disease.

Adolescent↗
PubMed1977

Management of dental trauma in children and adolescents.

The emergency treatment of dental trauma has traditionally been handled in the emergency rooms of medical centers, or in the dental office. With increasing emphasis on comprehensive medical care, and the tendency of more recent graduates to locate in rural areas, there is a growing trend for physicians to be involved in providing emergency care for traumatic injuries to the dental and oral tissues. The authors discuss the etiology of dental trauma and the highly psychologic impact of such injuries upon the patient and parents. Techniques for prevention and a comprehensive plan are outlined for systematic history taking and examination. A classification of eight levels of dental injuries (5), techniques for the emergency, and subsequent restorative care are given. Emphasis is placed upon immediate care which can, if necessary, be provided by the physician pending referral to a dentist.

Child↗