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Biomedical subjects

S Baba

Publications and source records attributed to S Baba.

At least 991 records · Page 55Linked to original sources

[Massive hepatic resection for metastatic cancer associated with Dubin-Johnson syndrome. Report of a case].

Massive hepatic resection was carried out on a 42 year-old female who had metastatic lesions of the colonic cancer in right lobe of the liver, which was accompanied by Dubin-Johnson syndrome. The following observations were made. Patient with Dubin-Johnson syndrome tolerated major hepatectomy. As for postoperative regeneration of the liver, there was no difference in comparison with the normal liver. Dubin-Johnson pigments in the hepatocytes decreased in proportion to hepatic regeneration for two months after hepatectomy. Therefore, it might be concluded that Dubin-Johnson syndrome is not poor risk factor for major surgery and massive hepatic resection.

Adult↗

[Renal leiomyosarcoma associated with penile carcinoma: a case report].

A case of renal leiomyosarcoma in a 55-year-old male is presented. The patient also had penile carcinoma. We believe this is the first report of renal leiomyosarcoma associated with penile carcinoma. Since 1957, thirty four cases of renal leiomyosarcoma have been reported in the Japanese literature. Some diagnostic problems of renal leiomyosarcoma are discussed, and the association of penile carcinoma with other malignant tumors is reviewed.

Carcinoma, Squamous Cell↗

Presence of insulin-like immunoreactivity and its biosynthesis in rat and human parotid gland.

Extracts from homogenates of rat and human parotid glands contained insulin-like immunoreactivity. The values were 5.6 +/- 2.8 ng/g wet tissue in six groups of rat parotid glands and 23.8 and 39.7 ng/g wet tissue in two human extracts. Upon gel filtration immunoreactive insulin of rat origin was eluted in a peak corresponding to the elution volume of isotopically labelled insulin. The material obtained from the two peak fractions showed an immunoassay dilution curve identical with that of rat insulin. Furthermore, biosynthesis of insulin-like immunoreactivity in rat and human parotid glands was confirmed in vitro by a specific separation method using anti-insulin antibody. These findings suggest that the parotid gland may be a further extrapancreatic source of insulin, and that insulin biosynthesis does occur in extrapancreatic tissues.

Animals↗

Salivary-type hyperamylasemia in primary lung cancer: observation of a possible precursor of the salivary-type isoamylase.

Although recent studies by column chromatography and electrophoresis showed that elevated amylase activity in the body fluids and tumor extracts in patients with primary lung cancer was mainly in the salivary-type isoamylase, neither mechanism nor mature of elevation of amylase have been clarified yet. This study was undertaken in order to make clear the nature of amylase elevated in the body fluids and tumor extracts of patients with primary lung cancer. In addition, amylase contained in the extracts of normal lungs and diseased lungs of patients who had died of various diseases was also studied. Our results revealed that amylase elevated in the body fluids and tumor extracts in patients with primary lung cancer was the salivary-type isoamylase and, moreover, that small amounts of salivary-type isoamylase in normal lung tissues and large amounts in diseased lung tissues were also contained. These facts suggested that salivary-type isoamylase was physiologically contained in normal lung tissues and large amounts in diseased lung tissues were also contained. These facts suggested that salivary-type isoamylase was physiologically contained in normal lung tissues and might be activated through pathological processes, such as inflammation, circulatory disturbance or tumor formation. Two peculiar isoamylases with cathodic mobility on polyacrylamide gel electrophoresis were found. One of them was so unstable that it was converted to the stable salivary-type isoamylase, suggesting the precursor of human salivary isoamylase.

Adenocarcinoma↗

The effects of chlorotrianisene (Tace) of kinetics of 3H-testosterone metabolism in patients with carcinoma of the prostate.

Alterations in the metabolism of testosterone and plasma levels of testosterone, luteinising hormone (LH), follicle stimulating hormone (FSH), prolactin and oestradiol were studied in 6 patients with newly diagnosed prostatic carcinoma before and during treatment with chlorotrianisene at a daily dosage of 48 mg for 14 days. Parameters of plasma kinetics were determined according to the single injection technique and the 2-compartment model, and the plasma hormones by radioimmunoassay. Chlorotrianisene altered neither plasma levels of testosterone, gonadotrophins, prolactin and oestradiol, nor metabolic clearance rate, production rate and other kinetic parameters of testosterone. Thus the beneficial effects which have been reported previously cannot be explained by suppression of peripheral testosterone metabolism.

Aged↗