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Biomedical subjects

S C Jacobs

Publications and source records attributed to S C Jacobs.

At least 145 records · Page 8Linked to original sources
PubMed1984

Priapism due to solid malignancy.

Although priapism secondary to hematologic malignancies has been well described, review of the literature reveals 75 case reports of priapism due to local corporeal involvement by solid tumors. Our recent experience with 6 cases of local invasion of the corporeal bodies is reviewed. Three transitional cell carcinomas, one prostatic adenocarcinoma, one rectal carcinoma, and one sarcoma comprise the series. Three patients presented with priapism as their chief complaint, and 3 patients presented with priapism as their first sign of recurrence. Therapy included corporeal curettage, surgery, radiotherapy, or chemotherapy. None of the modalities was entirely effective, although chemotherapy seemed to offer the best palliation.

Aged↗
PubMed1983

Renal oncocytoma. A clinicopathologic study.

Seven cases of renal oncocytomas are described. Two cases were from recent surgical and autopsy material seen within a period of ten months. Four cases were reclassified as renal oncocytomas from a 20 year review of 63 renal cell carcinomas removed operatively. One case was identified from a nine year review of 31 renal cell carcinomas coded in our autopsy files. All patients were males; mean age was 69 years. The smallest tumor measuring 0.3 X 0.3 X 0.3 cm represents the smallest renal oncocytoma reported. The largest tumor weighed 2350 g. It is the largest renal oncocytoma so far reported in the literature. Two of the cases were found in polycystic kidneys. None of the seven patients presented with symptoms related to the tumors and the subsequent clinical course was benign in all cases. Differential diagnosis from renal cell carcinoma is discussed in terms of light and electron microscopic and radiologic aspects. The previously reported cases in the literature are reviewed.

Adenocarcinoma↗
PubMed1983

Retrograde method for percutaneous access to kidney.

A technique is described for gaining percutaneous access to the kidney by puncturing from inside out using a retrograde catheter and a sharpened stainless steel stylet. The method allows precise placement of a percutaneous tract in the nondilated upper urinary tract.

Animals↗
PubMed1983

Epidermal growth factor is not the major growth-promoting agent in extracts of prostatic tissue.

Extracts of benign prostatic hyperplasia (BPH) contain a factor which is mitogenic for human foreskin fibroblasts in culture. Because of the similarity of BPH extract and epidermal growth factor (EGF) in stimulating quiescent fibroblasts to divide, it was of interest to determine if the prostate-associated growth factor competes for EGF receptor binding. BPH extract was found to compete poorly for 125I-EGF-receptor binding, did not influence the dissociation of cell-bound 125I-EGF and caused only a slight down-regulation of the EGF receptor. These findings indicate that EGF and BPH extract do not recognize the same receptor and that the major growth stimulating activity of BPH extract is not due to EGF.

Binding, Competitive↗
PubMed1982

Pathologic effects of pre-cystectomy therapy with combination intra-arterial doxorubicin hydrochloride and local bladder hyperthermia for bladder cancer.

Nine patients with bulky pelvic bladder cancer underwent combination doxorubicin hydrochloride hypogastric artery infusion and local bladder hyperthermia as a preoperative adjunct to radical cystectomy in a phase I study. Pathologic examination of the cystectomy specimens showed extensive tumor necrosis on the bladder luminal side, with a gradient of tumor destruction to viable tumor on the bladder serosal surface in 8 of the 9 bladders. Normal portions of the bladder showed minor changes in the urothelium, marked submucosal edema and hyperemia, and viable detrusor muscle. One bladder showed no viable tumor and fibrosis of the entire bladder wall. Adjunctive preoperative hypogastric artery infusion of doxorubicin hydrochloride/bladder hyperthermia is safe, well tolerated and merits further study to determine the upper limits of safety of doxorubicin hydrochloride and hyperthermia temperature.

Aged↗
PubMed1981

Congenital renal arteriovenous malformations.

Congenital renal arteriovenous malformations are rare, but their incidence are frequency of recognition are rising. Six cases of both cirsoid and idiopathic varieties are described. Patients were either asymptomatic or presented with gross hematuria and flank pain. Physical findings included hypertension, cardiomegaly, flank tenderness, and an abdominal bruit. IVP findings included filling defects in the renal pelvis from blood clots, irregular mucosal pattersn, or mass effect. Angiography demonstrated either single, simple, vascular channels or multiple, complex, varix-like communications. In both there was early filling of the renal vein, a normal caliber to the feeding artery and draining vein, and no displacement of parenchymal vessles. Asymptomatic patients required no treatment. Surgical procedures that spare renal parenchyma are preferred.

Adult↗
PubMed1981

The surgical management of hereditary multifocal renal carcinoma.

A family was described recently in which renal carcinoma developed in 10 members in 3 consecutive generations. The cancer tended to develop in patients at an early age, and to occur in both kidneys and at multiple sites more frequently than in nonfamilial renal cancer. The finding of a balanced reciprocal translocation between chromosomes 3 and 8 in affected family members suggest that an inherited genetic defect predisposes to the development of this cancer in middle-aged patients and offers a marker for screening individuals at risk. We herein discuss the surgical management of 4 family members, the proband and 3 relatives, who were discovered on screening to have bilateral, multifocal renal cancer. Certain compromises in the principles of radical tumor surgery have proved effective in these 4 patients. Partial nephrectomy has resulted in total extirpation of the bilateral tumors with survivals of 2 to 4 years without need for chronic dialysis. The sequential order of surgical procedures is important since partial nephrectomy of the least affected side first allows a total nephrectomy on the more affected side to be done later, when necessary, without transient renal failure.

Adenocarcinoma↗
PubMed1981

Tissue culture of normal human post-pubertal prostate.

Total prostatectomies were performed in 10 young male cadaver renal donors and explant cultures were prepared in Falcon flasks. Growth of a monolayer of predominantly epithelial cells occurred rapidly (latent time 3-5 days) and the flasks became confluent within 15-17 days. The monolayers grew well even when a needle was used to circumscribe and remove the explants. Passaging of monolayer cells by seeding at a density of 5 x 10(5) resulted in the vigorous growth of epithelial cells. However, the cultures were eventually overgrown by fibroblasts. Similar explant cultures of benign prostatic hyperplasia or prostatic carcinoma demonstrated a longer latent time, rarely attained confluence, died after explant removal, and could not be passaged.

Adenocarcinoma↗
PubMed1980

Synchronous bilateral renal cell carcinoma: total surgical excision.

Sixty-one patients with bilateral synchronous renal cell carcinoma have undergone total excision of their neoplastic disease. True follow-up of the patients has been obtained from the surgeons or the patients themselves. Fifty-one patients underwent renal parenchymal-sparing procedures in one- or two-stage operations. Successful extracorporeal tumor resection was performed on 17 kidneys. The local tumor recurrence rate is 10%. Ten patients underwent bilateral nephrectomy with maintenance hemodialysis, and 4 of these underwent renal transplantation. The 69% survival rate of the group at five years is better than that of unilateral renal cell carcinoma.

Adenocarcinoma↗
PubMed1980

Mitogenic factor in human prostate extracts.

Extracts of human benign prostatic hyperplasia, well-differentiated prostatic adenocarcinoma, and normal post-pubertal prostate stimulate 3H-thymidine incorporation by resting phase cultures of fetal rat osteoblasts and fibroblasts. The stimulation is concentration dependent and reaches a maximum at twenty-four hours of incubation. Prostatic extracts are also mitogenic in cell cultures of newborn human foreskin fibroblasts and the human cell lines, BUD-8 and DoT. The growth-stimulating factor is both heat and trypsin sensitive indicating that the factor is either a protein or contains a protein moiety. The growth-stimulating activity is not related to prostatic polyamine concentration. Experiments also show the activity is not due to human prostatic acid phosphatase. A prostatic growth factor may explain the growth of fibrous nodules in benign prostatic hyperplasia and the osteoblastic response of bone to prostatic cancer.

Acid Phosphatase↗
PubMed1980

Acute motor paralytic bladder in renal transplant patients with anogenital herpes infection.

We report on 2 renal transplant patients in whom acute urinary retention developed after anogenital herpes infections. In 1 case a reversible bladder motor and sensory neuropathy occurred secondary to herpes simplex virus infections. In the other case a motor paralytic bladder developed secondary to an anogenital varicella-zoster infection. Documentation was by carbon dioxide cystometrography and denervation hypersensitivity testing. Both cases were reversible without alteration of the immunosuppressive regimens.

Acute Disease↗