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Biomedical subjects

S Dash

Publications and source records attributed to S Dash.

At least 73 records · Page 4Linked to original sources
PubMed1991

Fine needle aspiration as a primary diagnostic procedure of breast lumps.

Two hundred and sixty-seven patients from the ages between 17 to 70 years with breast lumps attending the Cytology Clinic of the Out-patients Department and Cytology Section of the Department of Pathology, M.K.C.G. Medical College, Berhampur (Orissa), were subjected to Fine-Needle Aspiration Cytology (FNAC). Sixty-four patients were discarded from study because of non-availability of biopsy specimens and unsuitable smears. When cytological results were compared with those of histological sections, 100 per cent correct diagnosis was made in chronic mastitis and lobular carcinoma, 94.24 per cent in infiltrating duct carcinoma and 84.60 percent in duct papilloma and with the maximum over diagnosis to the tune of 14.75 per cent was found in fibro-adenoma. An overall correct diagnosis was made in 88.67 percent of cases by FNAC.

Adolescent↗
PubMed1991

A survey of six genetic markers on the populations of Punjab and Rajasthan (India).

190 Punjabis (Hindus and Sikhs) of Chandigarh and 152 Hindus of Jodhpur (Rajasthan) were examined for six genetic markers, four of which (APO C-II, C6, C7 and FXIIIA) were not studied before in Asiatic Indians. For APO C-II and C7 only the common phenotype was found in a total of 229 and 99 subjects, respectively. For the remaining four markers the two samples were pooled since the gene frequency estimates were not significantly different: FXIIIA*2 = 0.205 +/- 0.016; C6*B = 0.366 +/- 0.037; PGM1*2 = 0.247 +/- 0.017; PGD*C = 0.041 +/- 0.008. These data may contribute to evaluate the extent of the Mongoloid genetic admixture into the Caucasoid gene pool of the Punjab and Rajasthan Hindu population.

Apolipoprotein C-II↗
PubMed1991

An association of acute myeloid leukaemia and multiple myeloma: a case study.

A case of denovo presentation of acute myeloid leukaemia with multiple myeloma is reported in a 32 years old male. He presented with pancytopenia and aleukaemic leukaemia. Bone marrow examination revealed presence of acute myeloid leukaemia and sheets of plasma cells. Serum electrophoresis showed a M protein which was characterised to be Ig lambda with decrease in normal immunoglobulin levels.

Adult↗
PubMed1991

A clinico-pathological study of six cases of hairy cell leukaemia.

Clinicopathological findings of six cases of Hairy cell leukaemia are presented. All the patients were males, the age ranged between 32-57 years. Complications of anaemia and neutropenia were common modes of presentation. Hepatomegaly and splenomegaly were present in all the cases whereas only 2 patients had lymphadenopathy. Severe pancytopenia was detected in 3 cases and circulating hairy cells were present in all the cases. Trephine biopsy done in all six patients was found to be diagnostic. Tartrate resistant acid phosphatase was detected in the hairy cells of 2 cases.

Adult↗
PubMed1991

Clinico-hematological characteristics in patients with kala azar. A study from north-west India.

Clinico-hematological features were analysed in 23 patients with kala azar. Fever and hepatosplenomegaly were the main presenting features. All patients were moderate to severely anemic (Hb 4.3-8.1 g/dl), 17 were leucopenic and 15 were thrombocytopenic. Bone marrow showed moderate to severe megaloblastosis in 11 cases, an increased number of plasma cells in 20 and megakaryocytic hyperplasia with abnormal morphology in 19 patients. Megakaryocyte numbers per smear were significantly increased (p = 0.01) in thrombocytopenic patients as compared to patients with normal platelet counts. Spleen size, Hb level, platelet count and number of plasma cells in the bone marrow were related to parasite load. In general the degree of parasitisation, spleen size and duration of illness correlated with some of the main hematological features. Thus splenic sequestration and ineffective hematopoiesis appear to be the main etiopathogenetic factors in the emergence of bone marrow changes and peripheral cytopenias.

Adolescent↗
PubMed1991

Significance of natural polymerized albumin and its receptor in hepatitis B infection of hepatocytes.

Lack of information regarding the presence of native albumin polymer in serum and its structural similarity to the one produced by glutaraldehyde treatment casts doubt on the postulate that hepatitis B virus attachment to hepatocytes is mediated through polymerized albumin. We used a sandwich enzyme-linked immunosorbent assay with murine monoclonal antibodies raised against glutaraldehyde-polymerized albumin to detect native albumin polymer in human serum and its cross-reactivity with other albumin polymers. Presence of polymerized albumin receptor on the HepG2 cell was studied by radioreceptor assay. Purified hepatitis B virus and synthetic peptide analogous to part of pre-S2 sequence (120-145) were used to study polymerized albumin-dependent attachment of the virus to HepG2 cells. Antibodies raised against pre-S2 peptide were used to inhibit the pre-S2 and hepatitis B virus attachment to HepG2 cells. Glutaraldehyde-treated polymerized albumin was found to be immunologically cross-reactive with native albumin polymer. Its levels were found to be significantly raised in sera of patients with liver diseases. Polymerized albumin has specific saturable receptor on HepG2 cells with two classes of binding sites of different equilibrium dissociation constant (Kd1 = (16 +/- 9.6)pmol/L and Kd2 = (1,019 +/- 172)pmol/L. Albumin monomer was unable to compete for the polymerized albumin receptor sites on HepG2 cells. Anti-pre-S2 antibodies inhibit hepatitis B virus and pre-S2 binding to hepatocyte by 40% and 70%, respectively. Added extraneous polymerized albumin and the antibody against it did not interfere with virus attachment to HepG2 cells.

Cross Reactions↗
PubMed1991

Assays for lupus anticoagulant: the sensitivity of different assays.

Fifty patients with systemic lupus erythematosus were studied for the presence of lupus anticoagulant using three different assays--kaolin clotting time, platelet neutralization test, and tissue thromboplastin inhibition test. Lupus anticoagulant could be detected in seven cases (14%) with the use of one test in cases with a partial prothrombin time with kaolin more than five seconds greater than normal. The detection rate rose to 20% (10 cases) when using all three tests, so a panel of three assays could identify lupus patients apparently at risk for thrombotic complications.

Blood Coagulation Factors↗
PubMed1991

Blood carboxyhaemoglobin levels in smokers of Indian cigarettes with and without filters.

Blood carboxyhaemoglobin levels showed no significant difference between smokers of Indian cigarettes with and without filters (14.66 +/- 1.85 vs 16.07 +/- 1.92%; p greater than 0.05), although the value was slightly lower in the former. This may be because filters do not provide protection against absorption of carbon monoxide in the smoke. Further study in a large number is required.

Carboxyhemoglobin↗
PubMed1991

46 XX male with dysgenetic testes.

A 46 XX male with dysgenetic gonad is described. The patient was brought up as a girl and reported with primary amenorrhoea and hirsutism. The pathogenesis and management strategy of this condition are briefly discussed.

Adult↗
PubMed1991

Iron overload: detection using a micromethod for iron-binding capacity.

Depending upon the transferrin saturation value, 214 serum samples were divided into three groups--iron overloaded (46 cases), iron deficient (61 cases) and normal (107 cases)--and tested with a micromethod based upon detection of unsaturated iron binding capacity. All the samples with iron overload could be distinguished from the other two groups, the results of the normal and iron deficient groups showing wide scatter and overlap. The high prevalence of iron deficiency anaemia and thalassaemia (iron overload) syndromes in India and other developing countries emphasises the need to differentiate these disorders at the earliest opportunity. The micromethod can be of immense help as it is a simple, rapid and inexpensive.

Anemia, Hypochromic↗
PubMed1990

Correlation between morphological and cytochemical heterogeneity of acute promyelocytic leukemia (APL) and its association with myelodysplasia.

Sixty one cases of acute promyelocytic leukemia (M3) were diagnosed between Jan., 1985 and Dec., 1988. Morphologically 46 cases (75.4%) were characterised as typical M3 and 15 cases (24.6%) as M3 variant. Typical M3 cases had higher number of hypergranular promyelocytes and Auer rods (P less than 0.001). The cytochemical stains of myeloperoxidase, Sudan Block and Black and chloroacetate esterase were strongly positive in M3 typical and mild to moderately positive in M3 variant cases. Alpha-naphthyl acetate esterase positivity with fluoride inhibition was seen only in M3 variant cases (80%). The clinical and haematological parameters including marrow blast count were not significantly different in the two groups. This study has shown that M3 variant cases more frequently express heteregenous cytochemical patterns and myelodysplastic changes.

Adolescent↗