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Biomedical subjects

S E Adam

Publications and source records attributed to S E Adam.

At least 91 records · Page 5Linked to original sources
PubMed1981

Distribution of 5'-nucleotidase and gamma glutamyl transferase activities in the tissues of the horse.

In the horse, 5'-nucleotidase (5'-NT) activity is found mainly in homogenates of lung, kidney, small intestine, mammary gland, liver and pancreas. Lower activities are present in brain and muscle. Activity can be demonstrated histochemically in the glomeruli and tubules of the kidney, in the sinusoidal borders of the hepatocytes and the bile duct epithelium as well as in the blood vessels of all organs. There is no significant difference between the 5'-NT activity in serum and plasma of normal horses and of horses suffering from a range of orthopaedic conditions. Previous findings that gamma glutamyl transferase activity is greatest in kidney and high in liver and pancreas have been confirmed.

5'-Nucleotidase↗
PubMed1981

Toxicity of Datura stramonium to sheep and goats.

The toxicity of daily oral administration of Datura stramonium to Desert sheep and Nubian goats was studied. The main clinical signs were disturbances in locomotion, fasciculation, hyperesthesia, rapid respiration, and reduced water intake. There were increases in the concentrations of aspartate amino-transferase and ammonia and decreases of total protein and magnesium in the serum of Datura-poisoned animals. In this study Desert sheep appeared to be more susceptible to the effects of Datura stramonium than were Nubian goats.

Animals↗
PubMed1981

The toxicity of Capparis tomentosa in sheep and calves.

Five Desert sheep and three Zebu calves were poisoned with daily oral doses of the dry leaves of Capparis tomentosa and died or were killed in extremis at various times after the commencement of dosing. The important clinical signs of Capparis poisoning in sheep and calves were weakness of the hind limbs, staggering, swaying, flexion of the fetlock and phalangeal joints, pain in the sacral region, inappetence and recumbency. There was decrease in the level of total protein and calcium and an increase of glutamic oxaloacetic transaminase (GOT), ammonia, sodium and potassium in serum. The main pathological changes were vacuolation of the neurons and axons in the spinal cord, with necrosis of the centrilobular hepatocytes and renal convoluted tubules and glomeruli.

Africa↗
PubMed1980

The effect of samorin (isometamedium chloride) on Trypanosoma evansi infection in mice.

Samorin (isometamedium chloride) was effective against T. evansi in mice given in single i.p. doses of 1 to 10 mg/kg. The administration of 40 mg/kg of samorin or above caused rapid death of mice and there were severe haemorrhages, degeneration and congestion in the liver, heart and kidney. The lesions in the liver and kidney were accompanied with reduced activities of ATP-ase, 5-nucleotidase, succinic tetrazolium reductase and glucose-6-phosphatase.

Animals↗
PubMed1979

Effects of Jatropha curcas on calves.

Jatropha curcas seed was fed to six calves at doses of 2.5, 1 and 0.25 g/kg once and to two other calves at 0.025 g/kg up to 14 days. The onset of toxic manifestations in the six calves was rapid and death occurred within 19 hours of administration. The two calves that received daily the lowest dose of J. curcas showed signs of poisoning and died within 10 to 14 days. The clinical signs of diarrhoea, dyspnoea, dehydration and loss of condition were well correlated with the pathological findings. There was an increase in aspartate aminotransferase, ammonia and potassium and a decrease in total protein and calcium in the serum of jatropha-poisoned calves.

Animals↗
PubMed1979

Toxicity of Jatropha curcas in sheep and goats.

The sequential development of the clinical signs and lesions in the organs of desert sheep and Nubian goats dosed with Jatropha curcas seeds at 0.05, 0.5 and 1 g/kg/day was studied. Diarrhoea, reduced water consumption, dehydration, sunken eyes, inappetence and loss in condition were the important signs of J curcas poisoning in sheep and goats. The main pathological changes were haemorrhage in the rumen, reticulum, lungs, kidneys and heart, catarrhal and/or haemorrhagic enteritis, hepatic fatty change, pulmonary congestion and oedema and straw-coloured fluid in serous cavities. An increase in the concentrations of AST, ammonia, potassium and sodium and a decrease in total protein and calcium were detected in the serum. Haematological changes were haemoconcentration and leucocytosis.

Animals↗
PubMed1978

Mycetomas in goats.

Naturally occurring mycetomas were found in 3 goats. Two had mycetomas on their hind legs and the third on its left scapula. In 2 goats the causative agents were identified by culture, histopathology and serology as Actinomadura madurae. In the remaining goat diagnosis was based only on histopathology and the causative agent was considered to be A. pelletierii. Despite minor differences between goat and human strains of A. madurae, it would seem that goats could be useful experimental models.

Actinomycetales↗