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Biomedical subjects

S Leodolter

Publications and source records attributed to S Leodolter.

At least 109 records · Page 6Linked to original sources
PubMed1983

Estimation of the uteroplacental perfusion by use of 113mIn-transferrin and an iterative regression method.

For the clinical evaluation of the uteroplacental blood flow the radioactivity curve over the placenta is recorded by means of a gamma scintillation camera and is calculated by iterative regression method. The flow curves were attributable with good clinical relevance to 3 perfusion types: perfusion type I indicates unimpaired uteroplacental flow. Type II is a transitional type to the pathological type III. Over two-thirds of the type III cases gave births to babies with signs of moderate to severe malnutrition and in 1 case an intrauterine death occurred.

Birth Weight↗
PubMed1981

[Endometrial bacteriology in puerperal infections (author's transl)].

From the third to the sixth day postpartum transcervical endometrial swabs were taken from 51 women with the clinical signs of endometritis, like fever over 38 degree C, uterine tenderness and purulent lochia using prereduced anaerobic transport-media. The specimens were cultured aerobically and anaerobically. 27 women had an endometritis following vaginal delivery, 24 following caesarian section. Following vaginal delivery aerobic bacteria were isolated in 85.2% of the cases and anaerobic bacteria in 62.9%, post caesarian section in 75.1% aerobic and in 83.3% anaerobic bacteria. A mixed aerobic/anaerobic infection was found in 48.1% following vaginal delivery and in 58.4% post caesarian section. The aerobes most frequently recovered were Staphylococcus epidermidis, E. coli, Enterocococci and Streptococci, the prevalent anaerobes were the grampositive anaerobic cocci, Peptostreptococcus and Peptococcus, and Bacteroides species. Our results suggest that anaerobic bacterial play an important role in the endometritis post partum and that frequently a polymicrobial aerobic/anaerobic infection is present. Therapeutically, anaerobes should be taken into consideration especially for the treatment of severer infections following caesarian section. In such cases the 5-Nitroimidazoles, such as Metronidazole or antibiotics effective against anaerobes as Clindamycin or Cefoxitin should be administered.

Anaerobiosis↗
PubMed1980

[Study of the utero-placental perfusion by means of a circulation model (author's transl)].

The radioactivity time curves recorded over the utero-placental unit after application of 250 microCi 113mIn-transferrin may be regarded as the sum of various functional factors and morphological components. In order to be able to evaluate the influence of one single factor on the course of the curve in-vitro experiments were performed using a circulation model and an artificial placenta designed by the authors. The experiments confirmed that a gradual rise of flow resistance - equal to that present in cases of EPH-gestosis - results in a gradual reduction of the flow. By simultaneously raising the systolic pressure the values recorded got normal lowering the systolic pressure to values equal to those observed in hypotension a gradual drop of the flow was evoked. The results show that a rise of flow resistance or a drop of the mean arterial pressure results in curves as seen in case of reduced maternal blood supply to the placenta.

Blood Circulation↗
PubMed1980

[Radioisotope lymphadenectomy in testicular tumors (author's transl)].

This paper presents a preliminary report of the first eleven patients with testicular cancer who underwent lymphadenectomy assisted by radioisotope techniques with a special designed gamma surgical camera. In cases of only partial carcinomatous infiltration the lymph nodes are well marked with the radioisotope. Additionally colour television gives the surgeon an objective continuous control of the actually dissected lymphatic tissue during all phases of surgery. In our experience the use of radioisotope-techniques and a gamma surgical camera seem to be of great value in improving lymph node extirpation in cases of testicular cancer.

Adolescent↗
PubMed1979

[Results of a long-term clomiphene citrate therapy in women with normogonadotropic menstrual disturbanes (author's transl)].

A total of 72 pregnancies was achieved in 59 women with menstrual cycle disturbances (WHO Type II) by administration of clomiphene. 27 of these pregnancies (34.7%) occurred only after more than three courses of cloimphene. A secondary classification of the patients was based on the symptomatic severity of the menstrual disturbance. Clomiphene (100 mg) was administered on the fifth day after the onset of menstruation for five days, whereby in one or two cases up to 19 courses had to be given. The group consisted of women who had rejected HMG-HCG therapy because of the possibility of multiple pregnancy. 59 pregnancies went to full term; 2 tubal pregnancies and 11 cases of miscarriage were recorded. The commencement of pregnancy was evaluated and the time of ovulation and the length of the luteal phase determined in women requiring up to three courses of clomiphene and those requiring over three courses. The investigation demonstrates that clomiphene therapy can be successful even after more than six courses of the drug. Side effects are minimal.

Adult↗
PubMed1979

[Pregnancy hypotension and fetal outcome].

A prospective study on 28 hypotensive pregnant women was carried out at the I. Department of Obstetrics and Gynecology, University of Vienna. Besides periodical controls of HCS and E3, placental perfusion measurings with isotopes were undertaken. The placental perfusions of hypotensive patients were, in comparison to normal cases, significantly reduced. Most of the neonates were evidently smaller than normals and showed dystrophic signs. It is suggested that in the light of our study a maternal blood pressure below 115/70 mmHg must be considered alarming.

Adolescent↗
PubMed1979

[Angiographic diagnosis of ovarian cancer (author's transl)].

The methods of examination which are usually used in cases of tumours of the lower abdomen are mostly not able to determine the site of origin of the lesion of its histology unequivocally. Angiographic examination techniques enable the definition of such tumours and very often allow the differentiation between benign and malignant lesions. Both hypogastric arteries are selectively or semiselectively catheterized using Seldinger's technique. Additionally, in most patients, aortography and selective catheterization of the inferior mesenteric artery is performed. So far the diagnosis of an adnexal tumour was made by angiography in 6 out of 30 patients. The typical angiographic criteria of ovarian carcinoma are cited and discussed. Our results show that in selected cases of suspected ovarian tumours angiography offers good results and, therefore, it deserves an important place among the different available clinical examination techniques.

Adnexa Uteri↗
PubMed1979

The results of isotope renography and intravenous pyelography in 420 patients with carcinoma of the uterine cervix.

A group of women with carcinoma of the cervix was studied by renography and i.v. pyelography. The incidence of renal and urinary tract disorders detected by these tests increased as did the stage of the disease, being 17.1% with Stage I carcinoma of the cervix, 27.8% with Stage II carcinoma of the cervix, 47% with Stage III carcinoma of the cervix, and 83.3% in Stage IV carcinoma of the cervix. In patients with Stage I and Stage II carcinoma of the cervix, those selected for radiotherapy had twice the incidence of abnormal renograms as those selected for surgery. This difference probably reflected a higher incidence of medical disorders affecting renal and urinary tract function in those considered unfit for surgery. We believe that renograms should be used routinely as a screening test in patients with carcinoma of the cervix.

Female↗
PubMed1979

[Clinical significance of arteriovenous shunt malformations in the uterine and adnexal region (author's transl)].

This case report describes and discusses the entity of arteriovenous shunt malformations in the uterine and adnexal region. The diagnostic measurements and clinical importance of this disease is also outlined. The condition is rare, but should be considered in cases of severe hemorrhage when routine investigations have been normal. For the first time bloodgas-analytic measurements showing the extent of the shunting have been performed with such a disease.

Adnexa Uteri↗
PubMed1979

Maternal hypotension: fetal outcome in treated and untreated cases.

Within the last 3 years a prospective study on 70 pregnant women suffering from hypotension was carried out. In all these patients the endocrine placental function was examined regularly by measuring the HPL and E3 level in the maternal serum (from the 16th week of pregnancy onwards). In order to get information on the uteroplacental perfusion rate, placental flow measurements using radioisotopes were carried out. Whereas the endocrine parameters revealed no abnormality, the results of the flow measurements were significantly low in more than 80%. In 30 out of the total of 70 patients no medication was given and after termination of pregnancy the fetal outcome was investigated. The neonates of this group were significantly smaller than normal, the rate of dystrophy was considerably high. The other 40 women were subjected to a drug regimen. Depending on pressure values and type of complaints they were given a crystal suspension of deoxycorticosterone trimethylacetate intramuscularly. In this group of patients the placental perfusion rate improved significantly after medication, the fetal outcome did not differ in comparison to cases with normotension. In the light of our study we suggest that a maternal blood pressure of 110/65 and below has to be treated not only because of maternal indication, but as well because of the fetus' sake.

Birth Weight↗
PubMed1979

[Cost benefit analysis of the program for the improvement of perinatal mortality and morbidity in Austria (author's transl)].

A retrospective cost benefit analysis is initiated for the program to improve the perinatal mortality and morbidity in Austria which was started by the Federal Ministry for Health and Environment in 1974. Based on the official registry of birth in Austria the expenses for the intensive maternity care and delivery are calculated. From 1974-1978 the perinatal mortality of 2,514 children was prevented. It is assumed that for each prevented case of perinatal mortality two cases of cerebral damage were prevented. The benefit is calculated as alternative cost. The comparison of cost and benefit showed an approximate balance.

Austria↗
PubMed1979

[The influence of ritodrine-hcl (prepar), bunitrolol (stresson) and oxytocin (syntocinon) on Uteroplacental perfusion (author's transl)].

The administration of betamimetics has proved to be useful for symptom-oriented treatment in patients with reduced utero-placental flow. In order to quantify the betamimetic effect flow measurements were carried out in a total of 12 sheep, yielding the following experimental results: 1) Betamimetics, up to a certain point which correlates with maternal heart rate, raise the uteroplacental flow-rate. 2) The use of cardio-selective betablocker prevents undesired betamimetic side-effects but there is also a loss of the rise in utero-placental flow rate. 3) In sheep pretreated with Oxytoxin the application of betamimetics not only offsets oxytoxin-action but also greatly improves utero-placental blood flow.

Animals↗
PubMed1979

[The Le Veen peritoneo-jugular shunt and the testing of its function].

A radioisotope technique for testing the patency of, peritoneo-venous shunts of Le Veen, is reported and is demonstrated by discussing a case history. By now a total number of 16 patients have been tested, after implantation of such a shunt. The demonstrated radioisotope technique, which causes no complaints from the patient, is not only able to inform concerning the functional state of the Le Veen shunts, but also, in case of disturbances, is able to reveal the cause of the underlying malfunctions.

Ascites↗
PubMed1978

[Prophylactic medication to prevent miscarriage in pregnant women with a history of sterility (author's transl)].

A report is given of the outcome of 451 pregnancies occurring among women who had previously attended the Infertility Clinic. General gestagen therapy was given prophylactically in 129 cases before the appearance of any signs of threatened abortion. Massive gestagen therapy was initiated in 41 cases in response to signs of threatened abortion. Gestagen was not given either prophylactically or therapeutically in the remaining 281 pregnancies. The incidence of abortion was 10.1% in women given prophylactic gestagen, whilst the overall rate of abortion in the entire series of 451 women was 13.3%. It transpired on closer scrutiny of the 129 cases given prophylactic gestagen therapy that the abortion rate was 12.0% in the 108 pregnancies in which prophylactic gestagen therapy had been initiated at the time of the first missed period or later, whereas not one single abortion was registered amongst the 21 women who had been given gestagen therapy in the immediate post-ovulatory phase. It can be concluded that commencement of prophylactic gestagen therapy at the earliest possible moment provides optimum conditions for successful implantation of the fertilized ovum, especially in cases with masked insufficiency of the corpus luteum.

Abortion, Threatened↗