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S M Kuznetsova

Publications and source records attributed to S M Kuznetsova.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Heteromorphism of chromosome 1, 9 and 16 homologues in high- and medium-longevity level regions.

Regional and age-related peculiarities of chromosomal polymorphism are established as a result of studies in C-band heteromorphism of chromosomes 1, 9 and 16 in the long-lived subjects, their relatives and population groups of the Abkhazian and Ukrainian regions. Heteromorphism frequencies of chromosomes 1 and 9 homologues are high in the Abkhazian as compared with the Ukrainian regions. Age-related differences as to the degree of expression of chromosome 9 C-band heteromorphism found are as follows: in the Abkhazian region the frequency of variants with a high degree of heteromorphism increases with age, while in the Ukrainian region, with a low degree of heteromorphism, it decreases.

Journal Article↗
PubMedDate not supplied

Brain monoamine oxidase and aging: a review.

The present state of research on the age-related dynamics of brain monoamine oxidase (MAO) activity and its role in the development of age pathology is described. Special attention is given to the role of MAO in the pathogenesis of parkinsonism and to the mechanisms of its interaction with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a possible etiological factor of parkinsonism development in aging. The mechanisms of action of the selective MAO-B inhibitor, deprenyl, and their peculiarities in old age are analyzed. This study provides evidence pointing to a need for the use of deprenyl in geriatric practice as an effective drug for parkinsonism treatment and as a potent geroprotector.

Journal Article↗