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Biomedical subjects

S R Pattyn

Publications and source records attributed to S R Pattyn.

At least 91 records · Page 5Linked to original sources
PubMed1984

Comparative study of two regimens of combined chemotherapy of one year duration in multibacillary leprosy. Results after four and five years' follow-up.

Two therapeutic regimens of one-year duration were administered to two groups of 20 previously untreated multibacillary leprosy patients. Regimen A was rifampin 600 mg twice weekly, prothionamide 500 mg, and dapsone (DDS) 100 mg daily for six months, followed by 100 mg DDS daily for another six months. Regimen B was identical to Regimen A but without prothionamide. Follow-up was for 4 1/2 and 5 years in 15 and 14 patients, respectively. Clinical improvement was rapid, and the bacterial index (BI) of the patients diminished by one unit per year after stopping treatment. Five patients were skin-smear negative at 54 months. The BI in the nasal mucosa became negative after 48 months. There were many attacks of erythema nodosum leprosum between month 3 of treatment until 13 and 21 months. Up to now no relapses have been observed. These results have confidence limits of 20% and 23%, respectively. However, when the results of the two regimens are added, the confidence limit for six months' twice weekly rifampin together with DDS and followed by six months of DDS and 4 1/2 years follow-up is 12%.

Adolescent↗
PubMed1983

Cellulitis caused by Vibrio alginolyticus.

A case of cellulitis, resulting in a recurrence of a leg ulcer is presented due to the unique association of its bacterial flora, consisting exclusively of V. alginolyticus and of its clinically rapid expansion after seabathing.

Adult↗
PubMed1982

In vitro sensitivity of Mycobacterium lepraemurium for antimycobacterial drugs.

The sensitivity of Mycobacterium lepraemurium for isoniazide, dapsone, ethionamide, pyrazinamide, rifampicin, p-aminosalicylic acid, ethambutol and various sulfonamides was determined using Ogawa medium. The sensitivities of M. lepraemurium for these drugs are different from those obtained with M. leprae. Our results illustrate that M. lepraemurium is not a model for the drug sensitivities of M. leprae.

Anti-Bacterial Agents↗
PubMed1982

Sensitivity of mycobacteria to dapsone.

Dapsone sensitivity was tested on Loewenstein-Jensen medium on 164 mycobacterial strains belonging to 32 different species. A minimum inhibitory concentration as low as that of M. leprae, as determined "in vivo" was never observed. The most sensitive strains belong to the species M. kansasii, M. ulcerans, M. gordonae, M. szulgai and M. gastri with minimal inhibitory concentrations varying between 0.3 and 0.1 microgram/ml, still approximately 10 times the value known for wild strains of M. leprae.

Dapsone↗
PubMed1982

A comparison of the bactericidal activity of a series of rifampicins against Mycobacterium leprae.

The bactericidal activity against Mycobacterium leprae of six 3-(4-methylpiperazin-1-yl-iminomethyl)rifamycin SV (rifampicin) derivatives was compared with that of rifampicin in a modified proportional bactericidal test, using a smaller number of experimental animals and allowing the administration of a single dose of the drugs. No correlation was found between the in vitro activity of the rifamycin derivatives against M. tuberculosis or rapidly growing Mycobacteria in vitro and the activity against M. leprae in he mouse. The procedure is valuable for the screening against M. leprae of very potent bactericidal drugs available in only small quantities.

Animals↗
PubMed1981

Characterization of some ungrouped viruses.

Bangui, Bobaya, Kowanyama, Upolu and Zinga are enveloped spherical RNA viruses sensitive to ether and acid pH; morphologically resembling Bunyaviridae, their diameters range from 90 to 100 nm and their bouyant density is 1.17 to 1.18 g/ml in sucrose. St. Floris, a bunya-like virus, serologically related to Rift Valley Fever, has a diameter ranging from 90 to 110 nm. Triniti, Zingilamo, IPYM 120 and virus strain AnB4268 are enveloped spherical RNA viruses sensitive to ether and acid pH, have diameters of 65, 55, 55 and 60 nm and bouyant densities of 1.18, 1.24, 1.20 and 1.18 g/ml in sucrose, respectively; morphologically they resemble Togaviridae. Salanga is a poxvirus measuring 190 X 225 nm. Virus strain AnY1444 is a spherical, non-enveloped RNA virus measuring 85 nm, morphologically resembling Reoviridiae; it is restraint to both ether and acid pH and shows two-peak densities of 1.32 and 1.36 g/ml in caesium chloride. Bangoran, Keuraliba and Yata resemble Rhabdoviridae measuring 60 X 175, 65 X 195 and 60 X 185 nm, respectively.

Arboviruses↗