Six children (1 month to 5 years old) with DIC were treated with bolus injection of AT-III concentrates and/or continuous heparin infusion. In one case, when AT-III concentrates were administered without heparin, the platelet count was normalized in accordance with a rise in the plasma AT-III level. In the other children, who were treated with both AT-III concentrates and heparin, most of the abnormalities in coagulation studies were normalized within 5 days in four of five cases. These findings suggest that the administration of AT-III concentrates may significantly enhance the therapeutic efficacy of heparin, and that the use of AT-III concentrates with heparin is a safe and effective regimen for the treatment of childhood DIC.

Antithrombin III↗

PubMed1985

[A case of acute renal failure showing deposition of hepatitis Be antigen in glomeruli associated with acute exacerbation of hepatitis B (not fluminant type)].

Explore the source record for details and available documents.

Acute Kidney Injury↗

PubMed1984

Pure red cell aplasia: relationship between inhibitory activity of T cells to CFU-E and erythropoiesis.

T cell-mediated inhibition of autologous late erythroid colony formation was found in two patients with PRCA. Each patient was treated separately with immunosuppressive agents, ALG, bolus methylprednisolone or cyclophosphamide. Cyclophosphamide was the most effective among these immunosuppressive therapies. Peripheral blood T cells, which were taken serially from the patients during the course of the disease, were cryopreserved until use. The inhibitory activity of T cells was assayed after remission using autologous bone marrow. It was found that the decrease of inhibitory activity was closely correlated with clinical improvement and that the effectiveness of the immunosuppressive therapy on inhibitory activities of T cells differed between therapies. These findings suggest that T cell-mediated inhibition of erythropoiesis may be pathogenetic for PRCA in some patients.

Adult↗

PubMed1984

Megakaryoblastic transformation of chronic myelogenous leukaemia in a child.

A child with megakaryoblastic transformation of Ph1-positive chronic myelogenous leukaemia, complicated by myelofibrosis, is reported. The blastic cells were negative for myeloperoxidase by ultrastructural cytochemistry. They had Factor-VIII antigen and platelet glycoprotein but were negative for platelet peroxidase activity. This discrepancy seemed to be due to neoplastic origin of blastic cells.

Antigens↗

PubMed1984

Bone marrow failure in dyskeratosis congenita.

We report a case of dyskeratosis congenita ( DCG ) with neutropenia, lymphocytopenia and thrombocytopenia. Peripheral blood T lymphocytes (T cells) were proved to have a suppressive effect on the colony forming unit granulocyte-macrophage (CFU-GM). Splenectomy caused a transient increase of neutrophil count with the disappearance of the suppressive T cell activity. However, pancytopenia recurred without re-appearance of suppressive T cell activity.

Adolescent↗

PubMed1984