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Biomedical subjects

T Takatori

Publications and source records attributed to T Takatori.

At least 145 records · Page 8Linked to original sources
PubMed1979

Effects of phenylmethylsulphonylfluoride on activities of cholesteryl ester synthesis and hydrolysis in testes of rats, and on serum testosterone and LH levels.

PMSF was injected subcutaneously to male rats once a day for 10 days at a dose of 10 mg/day. There was an increase in the concentrations of free and esterified cholesterol in the testes, a decrease in activities of cholesteryl ester synthesis and hydrolysis but no change in activity of cholesterol side-chain cleavage enzyme. Serum testosterone and LH levels were significantly decreased. The only effect of PMSF on the lipids of the testes was a marked elevation of docosapentaenoic (22:5) acid and the cholesteryl esters.

Animals↗
PubMed1979

[Studies on the estimation of the postmortem interval. 9. Synthetic judgment of all sorts of cadaveric findings (author's transl)].

The authors have investigated the relationship between the postmortem interval and all sorts of cadaveric findings, summarizing the results of the previous reports, and have devised a cadaveric-phenomena diagram and a chart with which the postmortem interval can be estimated easily. The validity and utility of the diagram and the chart have been demonstrated by applying them to other autopsy cases than those from which they have been derived.

Adolescent↗
PubMed1979

[Medico-legal studies on the deaths from coal-mine accidents. 1. Cadaveric phenomena (author's transl)].

The authors have investigated the cadaveric phenomena on 30 persons killed in coal-mine accidents being kept in pits for a long time after death. The conclusions are as follows: The appearance and progress of cadaveric phenomena in pits depend on the postmortem interval alone, not on the immediate causes of death which have been found to be of seven classes in coal-mine accidents. The phenomena on cadavers kept in pits are the same as those in the air of normal temperature on earth. The reason may be that there are both accelerative factors and suppressive factors among various environmental factors in pits after occurrence of accident and they offset each other to make no difference between cadavers in pits and those on earth.

Accidents, Occupational↗
PubMed1979

[Medico-legal studies on the deaths from coal-mine accidents. 2. Exogenous findings (author's transl)].

Thirty-four deceased who were killed from twenty cases of coal-mine accidents during fourteen years from 1965 to 1978 were autopsied in our laboratory and the following conclusions have been obtained, summarizing the exogenous findings on the bodies. At the explosion of methane gas and coal dust chemical energy stored in coal or methane is converted to mechanical energy and thermal energy which act upon the human bodies. Mechanical energy produces diverse injuries in the human bodies, among which only the coal-particle impression demonstrates directionality. Thermal energy produces burns when it acts directly upon the human bodies and among diverse substances produced by heat from the explosion coal-tar like substance adheres to the skin, soot adheres to the inside of the air passage, carbon monoxide produces carbon-monoxide hemoglobin after entering the blood through the lung. At gas spurt mechanical energy stored in methane which is adsorbed on coal under high pressure is set free to produce injuries on the human bodies, but thermal energy does not develop. The action of diverse sorts of energy upon the body differs extraordinarily according to the distance from an epicenter or the irregularities of pit, producing various exogenous findings on the bodies. Accordingly, general rules cannot be established to assume the sort and mode of an accident and it should be considered on a case-by-case basis.

Accidents, Occupational↗
PubMed1979

[Medico-legal studies on the deaths from coal-mine accidents. 3. Causes of death (author's transl)].

Thirty-four deceased who were killed from twenty cases of coal-mine accidents during fourteen years from 1965 to 1978 were autopsied in our laboratory and their causes of death have been discussed. In the explosion of methane gas and coal dust chemical energy stored in coal or methane is converted to mechanical energy and thermal energy which act upon the human bodies to bring about seven sorts of causes of death. Deaths are caused more frequently by thermal energy directly or indirectly than by mechanical energy. It is a characteristic found in the explosions of coal mines which are large and closed underground spaces consisting of inflammable material. In gas spurt major cause of death is asphyxia from the lack of oxygen resulting from the substitution of air by methane gas and the effects of mechanical energy developed by gas spurt is slight in degree. In the coal-mine accidents the causes of death are so much concurred that is is difficult to certify the cause of death. A new concept of a cause of death has been proposed to solve such a problem.

Accidents, Occupational↗
PubMed1978

Effect of hypophysectomy of cholesteryl ester synthesis and hydrolysis in testes and on serum lecithin-cholesterol acyltransferase activity in rats.

Studies are reported of the effect of hypophysectomy on cholesterol esterase activity of testicular tissue and serum lecithin-cholesterol acyltransferase (LCAT) activity in rats. The testes of male Sprague-Dawley rats of 200-255 g were excised from animals sacrificed at 3, 7, and 15 days after hypophysectomy. Assays for cholesterol-esterifying and hydrolytic activities of the testicular tissues of these animals, compared to control animals, showed that hypophysectomy decreased both cholesteryl ester synthesis and hydrolysis. Hydrolytic activity was affected to a greater extent than esterifying activity. LCAT activity was significantly decreased by hypophysectomy compared to that of control animals. Although serum LCAT and testicular cholesterol esterase activities were decreased, the overall effect of hypophysectomy produced an increase in the level of serum cholesterol and cholesteryl esters. It is suggested that the role of essential fatty acids (EFA) in testicular function is related to the utilization of cholesteryl esters in androgen synthesis.

Animals↗
PubMed1978

Effects of prostaglandins on the metabolism of cholesteryl ester in rat testes: changes in the synthesis and hydrolysis of cholesteryl ester and the activity of cholesterol side-chain cleavage enzyme.

The effects of prostaglandins on testicular synthesis and hydrolysis of cholesteryl esters, the activity of the enzyme involved in cleavage of the cholesterol side-chain and on serum levels of testosterone and LH have been studied. Subcutaneous administration of prostaglandins to male rats caused an increase in the concentration of cholesteryl esters in the testes, a decrease in testicular synthesis and hydrolysis of cholesteryl esters but no change in the activity of the cholesterol side-chain cleavage enzyme. There was also a significant decrease in the serum level of testosterone, but the level of LH was raised. Prostaglandins also affected the fatty acid composition of lipids in rat testicular tissue; cholesteryl esters were found to contain greater amounts of arachidonic (C20:4) and docosapentaenoic (C22:5) acids. These findings suggest that prostaglandins are involved in the turnover of cholesteryl esters in rat testicular tissue and regulate the production of androgens.

Animals↗
PubMed1978

[Studies on the estimation of the postmortem interval. 2. The postmortem lividity (author's transl)].

The authors have investigated the relationship between the postmortem interval and the postmortem lividity of 430 persons who had died at known times and had been subjected to medico-legal autopsies. 1) For determining the postmortem interval from the postmortem lividity, the examination of the fading of the lividity upon pressure is most reliable. Among various methods of pressing, the pressing by means of a narrow side-edge of a hard instrument such as a pincette offers more accurate results than those by means of the fingerpressure which is commonly adopted in the present medico-legal practice. 2) The rate of nonfading is higher in summer among the cadavers within 6-12 hours after death, while over 12 hours it does not show any seasonal variation. Considering the influence of the cause of death, death by asphyxia and death by intracranial injuries show lower nonfading rate than death by exsanguination and natural death. These differences are observed merely within 24 hours after death. 3) Nonfading occupies one-third of cases during 6-12 hours after death and exceeds a half during 12-24 hours and exceeds two-thirds during 1-3 days and occupies almost all cases over 3 days. Namely, complete fading is observed within 3 days after death.

Adolescent↗
PubMed1978

Studies on the estimation of the postmortem interval. 3. Rigor mortis (author's transl).

The authors have devised a method for classifying rigor mortis into 10 types based on its appearance and strength in various parts of a cadaver. By applying the method to the findings of 436 cadavers which were subjected to medico-legal autopsies in our laboratory during the last 10 years, it has been demonstrated that the classifying method is effective for analyzing the phenomenon of onset, persistence and disappearance of rigor mortis statistically. The investigation of the relationship between each type of rigor mortis and the postmortem interval has demonstrated that rigor mortis may be utilized as a basis for estimating the postmortem interval but the values have greater deviation than those described in current textbooks.

Adolescent↗
PubMed1978

[Studies on the estimation of the postmortem interval. 4. Spontaneous opening and closing of the eyelids after death (author's transl)].

The authors have investigated the findings of 410 cadavers which were subjected to medicolegal autopsies in our laboratory as to whether their eyelids were open or closed at the time of autopsy and have come to the following conclusions. 1) It has been found that the eyelids of cadavers may open or close spontaneously as a cadaveric phenomenon. In about 27 per cent of cadavers dead from 6 to 12 hours the eyelids were open and thereafter they were closed gradually and all of them were closed from 36 hours to 4 days. After 4 days the eyelids of some cadavers were open again. The mechanism of this cadaveric phenomenon has been discussed. 2) Concerning the opening or closing of the eyelids, neither seasonal variation nor variation by age except newborn infants has been found. In death from exsanguination many were open and in death from drowning and carbon monoxide poisoning all were closed. 3) The findings whether the eyelids of cadavers are closed or open may be utilized as a criterion for estimating the postmortem interval; the cadavers with open eyelids are estimated to have been dead less than 36 hours or over 4 days.

Adolescent↗
PubMed1978

[Studies on the estimation of the postmortem interval. 5. The turbidity of the cornea (author's transl)].

The authors have investigated the relationship between the postmortem interval and the turbidity of the cornea of 410 persons who had died at known times and had been subjected to medico-legal autopsies in our laboratory. The conclusions are as follows: 1) Differences due to the states of the eyelids of cadavers, either open or closed, gave rise to slight variations of the turbidity of the cornea only within 12 hours after death. Slight variations due to age and sex were seen only from 12 to 24 hours after death and only in the age group of 0 to 19 years. Seasonal variation was not seen on the cadavers which had remained indoors at the Hokkaido districts. 2) In death from exsanguination none became a state of the strong turbidity. In death from intracranial injuries and asphyxia the strong turbidity developed earlier than in the other types of death. 3) When the cornea is transparent, the time which has elapsed since death is less than 36 hours, with few exceptions, with eyelids either open or closed. On the cadavers with closed eyelids, the week turbidity of the cornea is seen between 6 hours and 3 days, the moderate turbidity between 12 hours and 2 weeks and the strong turbidity over 18 hours.

Adolescent↗
PubMed1978

[Studies on the estimation of the postmortem interval. 6. The putrefaction (author's transl)].

The authors have investigated ten kinds of putrefactive findings on 368 cadavers which were subjected to medico-legal autopsies in our laboratory and have come to the following conclusions. 1) Concerning the occurrence of the putrefactive findings, seasonal variation was not seen on the cadavers which had remained indoors in the Hokkaido districts. No variation due to age and sex was seen. The occurrence of the findings was less frequent in death from exsanguination, traumatic shock and cardiac tamponade. 2) The putrefactive findings can be utilized as a criterion for estimating the postmortem interval; the interval is estimated to be over 6 hours when the pericardial fluid is turbid, over 12 hours when exudation of putrefactive fluid, gas formation, blood-stained peritoneal fluid or blood-stained pericardial fluid is present, over 18 hours when greenish discoloration of the skin, network of the skin or blood staining of the endocardium or the endothelium is seen, over 2 days when bullae is present on the skin, over 5 days when the pericardial cavity is dry, within 6 days when none of them are present.

Adolescent↗
PubMed1978

[Studies on the estimation of the postmortem interval 7. Cadavers in the water and privy (author's transl)].

The authors have investigated 17 kinds of findings of 34 cadavers in the water and 17 newborn-infant cadavers in liquid feces-urine mixture in privies which had remained at known postmortem interval and had been subjected to medico-legal autopsies in our laboratory. The conclusions are as follows: The progress of the cadaveric phenomena in the water and liquid feces-urine mixture is slower than in the air. The time ratio of the progress of the phenomena in the media to those in the air is not the same for all kinds of the findings, and hence it is not possible to apply the criterion of the estimation of the postmortem interval for the cadavers in the air to those in the water and liquid feces-urine mixture by any correction.

Adolescent↗
PubMed1978

[Studies on the estimation of the postmortem interval. 8. Burned bodies (author's transl)].

The authors have investigated 15 kinds of findings of 30 bodies burned at known times and autopsied in our laboratory. The conclusions are as follows: As the criteria for determining the time of death, external findings of cadavers burned lose value considerably, but internal findings, especially undigested food in the stomach remain as valuable as in ordinary circumstances. The usual criteria can be applied with the same degree of success to burned bodies, because appearances of findings caused by cadaveric phenomena show neither acceleration nor retardation in bodies burned so far as they are not severely destroyed.

Adolescent↗
PubMed1977

[Studies on the estimation of the postmortem interval. 1. The temperature of cadaver (author's transl)].

The relationship was investigated between the postmortem intervals and the rectal temperatures of 35 persons who had died at known times and had been subjected to medico-legal autopsies after exposed to changed environments. The influence of air temperature, body size and cause of death upon the cooling rate of cadaver has been found to be complex and not to be analyzed quantitatively. It has been concluded that the time of death cannot be estimated merely by means of the temperature reading of cadaver.

Adolescent↗
PubMed1977

Metabolism of labeled fatty ozonides administrated intravenously in rats.

The distribution and metabolism of uniformly labeled fatty ozonides administrated intravenously in rats were studied. More than 90% of radioactivity was recovered in the lung tissue even 4 to 8 hr after injection of labeled ozonides, and approximately 60% of total radioactivity incorporated into the lung tissue remained as fatty ozonides. A slight amount of radioactivity, which was mainly incorporated into phospholipid and triglyceride, was recovered in liver and kidney.

Animals↗