Biomedical subjects
Publications and source records attributed to V Cerný.
Bilateral testicular tumours account for cca 2-4% of all testicular tumours. In 1975-1989 at the Urological Clinic of the Faculty Hospital with Policlinic in Olomouc a total of 272 patients with testicular tumours were treated, incl. 6 with bilateral tumours which developed successively. The interval between the development of the tumours was on average 5.8 years. All patients survive 1-9 years after the diagnosis of the contralateral tumour.
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The authors report on their findings of the tick Ixodes ricinus under urban conditions of Prague. The concrete data were taken as a basis for a general scheme of possible occurrence of this species in various town parts, determined by the state of vegetation and presence of large mammals. Discussed are also conditions for I. ricinus maintenance in another type of anthropogenous landscape, the spoil banks resulting from brown coal exploitation.
Fifty three samples of blood sera of women from infertile couples were investigated for presence of antibodies to zona pellucida. Using the immunofluorescence test, antibodies reacting with porcine zona pellucida could be detected in sera of women with unexplained infertility and also in the sera of a control fertile group. In most cases these antibodies could be adsorbed by porcine erythrocytes, indicating that the erythrocyte-like antigens are present in the porcine zona pellucida, as was confirmed by electron microscopic studies.
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Fifty-three patients with advanced Hodgkin's disease, most of them previously treated, received 8 to 16 courses of modified MOPP regimens (nitrogen mustard replaced by trichlormethine in arm A, with addition of vinblastine to the 4-drug regimen in arm B, and alternation of three drugs--trichlormethine, vincristine, and prednisone--with probably non-cross resistant two drugs--vinblastine and procarbazine in arm C). Thirty patients (57%) achieved complete remission. Higher complete remission rate and longer survival was recorded in patients treated with 5-drug regimens (arms B and C) as compared to the 4-drug regimen (arm A), but the differences were not significant. Higher complete remission rates were observed in asymptomatic patients, females, and patients with lymphocyte predominance and nodular sclerosis subtypes of Hodgkin's disease. Besides expected short-term toxicity, 4 out of 30 complete responders developed secondary malignancies (two acute myeloblastic leukemias, one hepatocellular carcinoma, and one cerebellar astrocytoma). Several other patients had serious toxicity which could be attributed to chemotherapy. Twenty-eight percent of the patients has been alive 15 to 18 years since the start of this study.
Duplication of the urinary pathways of a transplanted kidney makes the localization of the ureteral defect and its repair more difficult. The authors describe difficulties associated with detection of the site where urine escapes and with restoration of the continuity of the urinary pathways by pyelopyeloureterostomy in a female patient with transplantation of a kidney with low fissure of the ureter.
In a seven-month boy the authors diagnosed a concretion in the choledochus cyst and cystic dilation of intrahepatic bile ducts by ultrasonography. The finding was verified by surgery.
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One strain of Bhanja virus was isolated from Dermacentor marginatus male ticks collected from sheep in Slovak Karst, eastern Czechoslovakia (48 degrees 31'N, 20 degrees 28'E). In addition, three strains of Brezová virus (subtype of Tribec orbivirus, Reoviridae) were isolated from Ixodes ricinus ticks. The result represents the northernmost isolation of Bhanja virus and, moreover, its first recovery from D. marginatus in Europe. Cross-neutralization plaque reduction test revealed antigenic similarity of the Czechoslovak strain to the south-European isolates of Bhanja virus, but a more distant relationship to virus strains isolated in Africa and Asia.
Eight species of birds of the families Fringillidae (3), Motacillidae (2), Prunellidae (1), Pycnonotidae (1) and Turdidae (1) were found to be parasitized by 8 species of the genus Proctophyllodes, 3 of them being new to science: P. danieli sp. n. from Pycnonotus leucogenys, P. macrophallus sp. n. from Prunella collaris and P. puniceus sp. n. from Pyrrhospiza punicea. Other species recorded are P. anthi, P. cotyledon, P. glandarinus, P. leucosticti and P. aff. poublani. All hosts were collected in the region of the Barun river valley in East Nepal in the altitude of 3,600-4,900 m a. s. l.
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