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Biomedical subjects

V I Votiakov

Publications and source records attributed to V I Votiakov.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Peroxidase activity of the influenza virus].

The appearance of chemiluminescence has been detected in influenza virus-luminol-hydrogen peroxide system. An effective decrease of its intensity in the presence of oxygen radical scavengers (sodium azide, superoxide dismutase, mannitol, ethanol) is indicative of activated oxygen taking part in the reaction. Increased luminescence in the presence of o-phenanthroline and its suppression by antimycin A suggest that peroxidase-like activity of influenza virus is due to the presence in it of Fe-S-protein.

Animals↗
PubMed1985

[Ultrastructural changes in the CNS in amyotrophic leukospongiosis].

Various types of cells in the human spinal cord and brain, status spongiosus of the white matter of the spinal cord were studied by electron microscopy; the comparison was made to the status spongiosus in monkeys with experimental amyotrophic leukospongiosis. The alterations in the motor neurons of the spinal cord, pyramidal neurons of the brain hemisphere cortex and cerebellum ganglious neurocytes were revealed. Changes in some cells (astrocytes, olygodendrocytes) were characterized. The possibility of a primary axon damage in this disease is discussed.

Animals↗
PubMed1985

[Clinical and experimental amyotrophic leukospongiosis (progressive spinal amyotrophy)].

The authors succeeded in reproducing amyotrophic leukospongiosis in experiments on two squirrel monkeys 16-23 months after challenge with cerebral suspension obtained at autopsy from a human patient. The clinico-morphological studies showed the similarity of the disease in humans and monkeys. A previously unknown agent belonging by its properties to "slow" viruses was isolated. The successful reproduction of amyotrophic leukospongiosis under experimental conditions proved its infectious nature.

Animals↗
PubMed1983

[Patterns of the epidemic process in poliomyelitis with regular live vaccine immunization of the population].

The results of the study of epidemic poliomyelitis in Byelorussia in 1981-1978 are presented. Two consecutive phases of the epidemic process were established: the suppression of the infection and its elimination. In the suppression phase sporadic cases of poliomyelitis still persisted, due to reduced circulation of wild polioviruses. In the elimination phase no wild polioviruses were isolated and no cases of the disease occurred.

Adolescent↗
PubMed1982

[Morphological changes in the central nervous system in amyotrophic leukospongiosis].

A histological study of a peculiar progressive disease of the central nervous system (CNS) named amyotrophic leukospongiosis was carried out in 5 observations. The regular histological signs included the loss of motor neurons in the spinal cord and encephalon, the status spongiosus of the white matter in the anterior and lateral columns of the spinal cord and different parts of the white matter in the encephalon. Unlike amyotrophic lateral sclerosis, amyotrophic leukospongiosis is characterized by intact myelin fibers of the anterior and lateral columns (including pyramidal tracts). The clinical, epidemiological, and histological data allow the disease to be classified into the group of slow virus infections.

Adult↗
PubMed1982

[Clinical picture and diagnosis of amyotrophic leukospongiosis].

Within a period of 24 years 17 patients suffering from a specific spinal amyotrophy were observed in Byelorussia. The disease steadily progressed and ended in death. Family and group morbidity, and less frequently sporadic cases were registered. Clinical examinations revealed a selective affection of the anterior horns resembling subacute anterior poliomyelitis. The truncal structures remained intact during the whole course of the disease. Two or three years after the disease onset spinal disturbances of respiration joined. The average duration of the disease was 2.5 to 3 years. Morphological examinations revealed total destruction of thoracic mononeurons and spongiosis of the white matter of the brain and the spinal cord, but without signs of demyelinization of the corticospinal tract. The specificity of the epidemiological, clinical, and pathomorphological features of the disease has given the authors grounds to designate it as "amyotrophic leukospongiosis".

Adult↗
PubMed1981

[Transfer of resistance against Ixodes ticks to vertebrates with the sera and lymphocytes of immune animals].

Hyperimmune serum with the high content of antibodies to the saliva of noninfected ticks when injected into vertebrates, induced the development of resistance preventing the ticks from sticking to the skin and satiation, thus reducing the number of blood-sucking ticks reaching satiation and decreasing the weight of satiated ticks; as a result, the productivity of female ticks decreased the the number of ticks sharply dropped. When ticks infected with tick-borne encephalitis virus parasitized on the animals immune against the saliva antigens of noninfected ticks, the virus titers in the blood of these animals were lower than in the controls, and no infection of ticks, formerly free of the virus, occurred.

Animals↗