PubMed Health⌕ Search

Biomedical subjects

V Kasantikul

Publications and source records attributed to V Kasantikul.

At least 73 records · Page 4Linked to original sources
PubMed1987

Spontaneous penetration of dura mater and bone by glioblastoma multiforme.

Three patients are reported whose cranial dura mater and bones were penetrated by intracranial glioblastomas in the absence of previous craniotomy or radiotherapy. The gliomatous nature of the tumors was confirmed by localization of cytoplasmic glial fibrillary acidic protein (GFAP) of the neoplastic cells. Review of the literature disclosed only 15 glioblastomas, including the three cases, spontaneously penetrating the cranial dura mater and bones. These patients ranged in age from 3.5 to 70 years with an average age of 40 years. The male/female ratio was 5/8. Five glioblastomas were in the temporal lobes, three were in the frontal lobes, three were in the frontotemporal regions, two were in the occipital lobes, one was in the frontoparietal region, and one was in the temporoparietooccipital region. Six glioblastomas also had spontaneous distant metastases. In the absence of previous craniotomy and radiotherapy, rapid growth of the glioblastomas may promote such spontaneous penetration into the cranial dura mater and bones.

Adult↗
PubMed1987

Primary phycomycosis of the brain in heroin addicts.

Two heroin addicts had fatal primary phycomycosis of the brain. The first case is unique. A 28-year-old man displayed unusual symptoms of unilateral hydrocephalus confirmed by both computed tomography (CT) scanning of the brain and craniotomy. The nature of the fungal granuloma was verified histopathologically. The second case, a 40-year-old man, possessed bilateral basal ganglionic lesions in which the CT scanning suggested abscesses. Postmortem examination confirmed the presence of phycomycotic abscesses. There was no evidence of systemic mycoses in both cases. Review of the clinical features of this fatal complication in drug abusers and narcotic addicts disclosed that hemiparesis and facial weakness are common. Brain or CT scan along with brain biopsy are necessary for rapid diagnosis and prompt treatment.

Adult↗
PubMed1987

Parapharyngeal malignant ectomesenchymoma: combined malignant fibrous histiocytoma and primitive neuroectodermal tumour with neuroglial differentiation.

A parapharyngeal ectomesenchymoma consisting of mixed malignant fibrous histiocytoma and primitive neuroectodermal tumour with neuroglial differentiation occurred in a 36-year-old woman. Immunohistochemical and electron microscopic studies verified the combined mesenchymal and neuroectodermal components within the tumour. Only 9 similar cases, including the present one, are on record. The patients ranged in age from 6 months to 49 years, with an average age of 18 years. The male:female ratio was 4:5. The tumour location was widespread. All reported ectomesenchymomas were histopathologically malignant. Recurrence and/or metastasis was/were common. The neural crest has been suggested as the origin of the ectomesenchymomas.

Adult↗
PubMed1987

A combined neurilemmoma and angioma of the parasellar region. Case report.

A combined neurilemmoma and angioma of the parasellar region is presented that clinically simulated a pituitary tumor. The lesion produced increased intracranial pressure and subarachnoid hemorrhage (SAH). This neoplasm is believed to have originated from the leptomeninges or the perivascular neural elements, or both. The angiomatous network within the tumor could have been the source of the SAH.

Female↗
PubMed1986

Cerebellar medulloblastomas: a study of 35 cases with particular reference to cellular differentiation.

A series of 35 cerebellar medulloblastomas was studied using light microscopy and immunohistochemistry for localization of glial fibrillary acidic protein, an antigen specific for neuroglia. Most medulloblastomas occurred in children less than 15 years of age (77.1%), especially in the first decade of life (65.7%), with the peak incidence (40.0%) between 6 and 10 years. The rest were found in adults beyond 15 years of age (22.9%). The male to female ratio was 4:3. Ependymal differentiation was observed in 100% of medulloblastomas, astrocytic differentiation in 88.6%, oligodendroglial differentiation in 34.3%, glioblastomatous differentiation in 8.9%, and neuronal differentiation in 8.9%. These data suggest that medulloblastoma is a primitive (stem cell) neuroepithelial neoplasm with the capacity of differentiating along both neuroglial and neuronal directions. Excessive mucin production was encountered in one medulloblastoma. Leptomeningeal invasion occurred in 34.3% of medulloblastomas and endothelial hyperplasia in 28.6%. One medulloblastoma (2.9%) spread postoperatively to several bones.

Adolescent↗
PubMed1984

Lipomatous meningioma associated with cerebral vascular malformation.

A unique epileptic patient with intracranial neoplasm is reported in which a meningioma with lipomatous and osseous components was found associated with cerebral arteriovenous malformation at the same location in the right frontal lobe. The development of the leptomeningeal neoplasm may have been influenced by the underlying vascular anomaly. The cerebral arteriovenous malformation and altered hemodynamics also could have induced the sudden onset of clinical seizures, hemiparesis, and unconsciousness.

Aged↗
PubMed1984

Malignant neoplasm of mixed mesenchymal and neuroepithelial origin (ectomesenchymoma) of thigh.

A 49-year-old man had a malignant soft tissue tumor of the right thigh with metastasis to the femoral region and lower quadrant of the anterior abdominal wall on the right side and the left supraclavicular lymph nodes. The neoplasm showed features of chondrosarcoma and primitive neuroectodermal tumor (combined neuroblastoma, ependymoma, astrocytoma, and oligodendroglioma). The gliomatous part of the mixed tumor was confirmed by identification of the glial fibrillary acidic protein (GFAP). The diverse cellular population suggests a tumor origin from the ectomesenchymal remnant of the neural crest. The mesenchymal component of the neural crest would differentiate into the chondrosarcoma and the neuroectodermal component into the primitive neuroectodermal neoplasm. These various neoplastic elements, then, would form a neoplasm of mixed mesenchymal and neuroepithelial origin or an ectomesenchymoma.

Astrocytoma↗
PubMed1984

Solitary primary intracranial extracerebral glioma. Case report.

A case is presented of a solitary primary extracerebral mixed glioma occurring in the right suprasellar and parasellar region of a 49-year-old woman who had bilateral temporal hemianopsia for 3 months. At craniotomy, the well demarcated outline and extracerebral location of the tumor suggested that it was a meningioma. However, its gliomatous nature was confirmed by identification of glial fibrillary acidic protein (GFAP) in the tumor cells. Review of nine reported solitary primary intracranial extracerebral gliomas, including the present case, revealed that they tended to occur in the third to fifth decades of life, in patients with an average age of 42 1/2 years, and without sexual predilection. All were supratentorial with a tendency to be situated in the vicinity of the Sylvian fissure. Only the glioma in the present case was at the cranial base. They were diagnosed as three astrocytomas, two glioblastomas, two oligodendrogliomas, one astroblastoma, and one mixed glioma. A suggestion is made that all these gliomas arose primarily from heterotopic neuroglia in the leptomeninges.

Brain Neoplasms↗
PubMed1983

Ultrastructural parameters of limbic microvasculature in human psychomotor epilepsy.

Temporal lobe tissues from seven patients with drug refractory complex partial seizures were extensively examined using both light and electron microscopy in combination with certain computer techniques. Four of these cases had mesial sclerosis, whereas three cases had no demonstrable lesions in the hippocampus as determined by intermittent serial sections. Transverse sections of hippocampus were made and rapidly fixed in the operating theatre. Blocks were taken after orientation to a close-up photograph of the fixed unstained hippocampus. Cross sections of capillaries at a level where the nuclear outline was largest were photographed at low magnification in the electron microscope. Enlarged prints allowed the use of a computer-assisted planimetry and stereology system for determining capillary thickness, mean basal laminar thickness, mitochondrial incidence, and mitochondrial area of both endothelial and perithelial cells and numbers of light junctions occurring in the capillaries. Comparison of sclerotic tissues versus control showed a significant increase in laminar thickness of the sclerotic endothelia and perithelia. In endothelial cells of the disordered cortex there were fewer mitochondria than in controls; also these same endothelial cells had greater numbers of tight junctions. These changes are related to ongoing hippocampal neuron degeneration, dysregulations of the blood-brain barrier because of possible resistance to perfusion, and interference with transcapillary transport in relation to [K+] levels in neuronal milieu.

Capillaries↗
PubMed1982

Mesenchymal differentiation in trigeminal neurilemmoma.

An unusual neurilemmoma of the trigeminal nerve in a 31-year-old woman is described. The neoplasm was roentgenographically calcified and contained various types of mesenchymal tissue, including a cavernous angioma, cartilage, bone, and adipose tissue. Angioma in combination with neurilemmoma occurs more frequently than other forms of mesenchymal tissue. Lipoma is an uncommon component of neoplasms affecting the cranial nerves. Cartilage and bone are rarely encountered in benign intracranial neurilemmomas. The histogenesis of this combined neoplasm is discussed in relation to the ectomesenchymal properties of the neural crest.

Adult↗