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Biomedical subjects

V P Kuznetsov

Publications and source records attributed to V P Kuznetsov.

At least 91 records · Page 5Linked to original sources
PubMed1982

[Antistaphylococcal activity in interferon preparations].

Antistaphylococcal bacteriostatic and bactericidal activity was detected in the preparations of human leucocytic interferon of the native type. Such an activity could not be neutralized by the interferon antibodies. However, it was usually lost during the process of interferon purification. It is concluded that this antistaphylococcal activity is not related to interferon and is due to other factors which can be isolated with induced leucocytes.

Animals↗
PubMed1982

[Effect of various forms of human leukocyte interferon on the natural killer activity of human lymphocytes].

The effect of the preparations of human leucocytic interferon (HLI) of various purity levels and of various concentrations was studied with respect to the natural killer activity of human leucocytes. It was shown that the process of purification and concentration of the preparation of HLI with the Kantel method entailed a disproportionally high loss of the activity stimulating the natural killer cells as compared to the antiviral activity.

Cytotoxicity Tests, Immunologic↗
PubMed1976

[Ribonuclease activity in preparations of human leukocyte interferon].

Preparations of human leukocyte interferon obtained by multi-stage purification procedure exhibited ribonuclease activity with the optimum at pH 7.0--7.5. The enzyme possessed the endonuclease action mechanism. Most substances studied for their effect on the RNA-ase activity in human interferon preparations showed many of them to act on the enzyme in the same way as on other ribonucleases. However, dithioerythritie, a reducing agent for disulfide bounds, activated the ribonuclease in the interferon preparation, as distinct from the pancreatic ribonuclease, which was inhibited by this preparation. Patterns of protein and RNA-ase distribution were obtained by electrophoresis in polyacrylamide gel.

Catalysis↗