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Biomedical subjects

W Abdulla

Publications and source records attributed to W Abdulla.

At least 19 recordsLinked to original sources
PubMed2005

Case report. Successful use of tenecteplase in massive pulmonary embolism with cardiopulmonary resuscitation immediately following tracheostomy.

The use of thrombolytics for the treatment of massive pulmonary embolism with cardiopulmonary resuscitation is being controversially discussed. This is one of the first reports on the successful use of tenecteplase in a 59-year-old man who survived a massive pulmonary embolism after tracheostomy followed by a 30-minute cardiopulmonary resuscitation without cerebral damage. In such a dramatic clinical event, the immediate and simple use of this modern thrombolytic appears to be a justifiable last-resort treatment option until controlled studies in sufficiently sized patient populations will have proven or refuted its efficacy and safety.

Amyotrophic Lateral Sclerosis↗
PubMed1985

[Hormone and metabolism behavior in distress without physical stress].

The psychological effects on cortisol, human growth hormone (HGH), free fatty acids and lactate were investigated in 10 healthy students using a one hour television game. To insure that only the psychological aspects of the game were being measured, hematocrit, creatininkinase, CK-MB and myoglobin were used as controls. The game began 60 minutes after venapuncture of a lower arm vein with an indwelling catheter. Blood samples were taken 30 and 60 minutes after venapuncture, at intervals of 20 minutes during the game and 30, 60 and 120 minutes after the end of the game. After an initial rise, plasma cortisol levels sank steadily and significantly (alpha = 1%). The HGH level initially fell, but as the game progressed, rose and remained at a high level for a considerable period after the game had ended. These variations however were not statistically significant. The three free fatty acids under investigations, myristinic acid (C14), palmitic acid (C16), and stearic acid (C18), all showed similar levels over the course of the experiment. During the first 20 minutes of the play, free fatty acid levels rose, with stearic acid levels rising the most (52%). The free fatty acid levels then sank as the game progressed, with the palmitinic acid level showing a significant decline (alpha = 1%). The other parameters remained relatively constant during the experiment, with the exception of the CK-MB level, which showed severe, hard-to-interpret variations.

Adult↗
PubMed1982

[Electrostimulation anesthesia in surgery of the retina and vitreous body].

Needling of acupuncture points combined with mechanical or electrical stimulation is insufficient for analgesia for surgical interventions. Therefore a new concept of anesthesia was developed: Electrostimulation has been combined with induction of anesthesia, relaxation and controlled ventilation with a mixture of N2O/O2. We have used this method of anesthesia in patients undergoing retinal and vitreous surgery. Our stimulation has been done by self-adhesive electrodes placed bilaterally in the area of trigeminal nerve and cervical plexus. The aim of this study was to investigate the stress response under electrostimulation anesthesia compared with neurolept anesthesia. Therefore the plasma concentrations of adrenaline, noradrenaline, cortisol and some metabolic parameters (glucose, glycerol, NEFA, ketone bodies) as well as heart rate and arterial blood pressure were measured before, during and after surgery. The changes in the parameters under surgery showed that ESA induces a higher stress reaction than NLA. The differences between the two groups are not significant.

Electronarcosis↗
PubMed1982

[Ketamine anesthesia in strabismus surgery--hormone and cardiovascular tests].

The effects of ketamine anesthesia on the sympathoadrenal and adrenocortical system, on plasma concentrations of somatotropine and insulin and the circulatory system were investigated in eight patients undergoing strabismus surgery. Therefore blood concentrations of adrenalin, noradrenalin, ACTH, cortisol, somatotropin and insulin as well as arterial blood pressure and heart rate were measured 30 min after premedication (I), 5 min after the initial injection of ketamine (II) and in steady state during the operation (III). Plasma adrenalin and noradrenalin levels were determined fluorimetrically by a modified trihydroxyindole technic; plasma cortisol, somatrotropin and insulin were determined by radioimmunoassay. All examined parameters--except insulin--showed significant changes after induced of anesthesia and during surgery compared to the respective pre-anesthetic values.

Adolescent↗
PubMed1982

[Chronic alcohol consumption and use of anesthetics - retrospective study of laryngectomies].

It was the purpose of this clinical retrospective study, which was conducted under homogeneous conditions, to find out whether there is a connection between chronic alcoholism and the consumption of narcotics. We examined a group of tumour patients who had to undergo partial laryngectomy in anaesthesia with neuroleptics. We examined 161 reports with regard to their statistical valuation. 21 patients were selected from group A in whom anaesthesia with neuroleptics had been induced with Thiopental, Droperidol and Fentanyl, and 48 patients from group B in whom anaesthesia with neuroleptics was induced with Flunitrazepam and Fentanyl. The patients of both groups were divided into three groups according to their previous alcohol history: Daily consumption of alcohol group I less than 20 ml, group II 20-100 ml, group III greater than 100 ml. Group A turned out to be too small for statistical valuation. But the mean values of Fentanyl consumption indicated dependence on the quantity of alcohol consumed. Group B was analysed statistically. In spite of the fact that there was a lack of statistical significance, the mean values for the consumption of Fentanyl (in group II higher by 7.8% and in group III higher by 16.9% than in group I) did show a dependence on alcohol abuse, the more so since signs of insufficient anaesthesia were reported by such patients only in whom severe abuse of alcohol had been established.

Alcohol Drinking↗
PubMed1981

[The effect of enflurane anaesthesia and operation on the sympathoadrenal and adrenocortical system (author's transl)].

The effect of enflurane anaesthesia on the sympathoadrenal system, the hypothalamic-hypophyseal-adrenocortical system, and on the circulatory system was investigated in patients undergoing ophthalmic surgery. Blood concentrations of adrenaline, noradrenaline, ACTH, cortisol, and arterial blood pressure and heart rate were measured in 10 patients 30 min after premedication (I), 3-5 min after surgical incision (II), 20 or 45 min after surgical incision (III) and in 7 of 10 patients 10-15 min after extubation (IV). After conventional induction anaesthesia was maintained with enflurane (1.5-2.0%), combined with N2O/O2 2:1, and intermittent relaxation. Plasma adrenaline, ACTH, cortisol and heart rate increased significantly during operation, while plasma noradrenaline and blood pressure did not change significantly. Thus enflurane anaesthesia could not completely inhibit the increased activity of sympathoadrenal and hypothalamic-hypophyseal-adrenocortical system caused by surgical stress.

Adolescent↗
PubMed1981

[The influence of electro-stimulation anaesthesia on the intraocular pressure (author's transl)].

The effect of electrostimulation anaesthesia was studied in 23 patients undergoing ophthalmic surgery. Intraocular pressure (IOP) was measured 30 minutes after premedication (I), immediately after intubation (II), after the start of stimulation and relaxation (III) and after the establishment of full relaxation and achievement of full stimulation (IV). After intubation IOP increased from 16.4 +/- 3.3 mm Hg to 19.4 +/- 5.6 mm Hg (p less than 0.05), but decreased at reading IV statistically significantly compared with reading I to 12.7 +/- 2.8 mm Hg. To investigate the effect of electrostimulation alone on IOP, we performed tonometry on 10 control persons, in whom we observed a rise in IOP which can be attributed to current induced contractions of the extraocular muscles. The results demonstrate that there is a direct relation between electrostimulation and extraocular muscles, and we find it essential to relax the patients sufficiently to avoid hazards of IOP elevation.

Electronarcosis↗
PubMed1981

[Circulatory pattern under electro-stimulation-analgesia and neurolept-anaesthesia in the same patient. A comparative study during retinal and vitreous body operations (author's transl)].

The present paper reports a comparative study on circulatory conditions of patients who underwent both electro-stimulation- and neurolept anaesthesia. Investigations were carried out in 20 patients who had operations on the retina or vitreous body, either under neurolept or electro-stimulation anaesthesia, and who had to undergo a second of those, so that both types of anaesthesia were administered in each patient. 50% of the patients were showing polymorbidity which is often observed in elderly persons; 5 of the cases were patients suffering from hypertonia which had previously been treated unsatisfactory. As measure for judging the circulatory conditions under either anaesthetic method, the plain measurable values of systolic and diastolic pressure and heart rate were registered. A statistical evaluation of the anaesthetic records was carried out with special consideration of circulatory stability and each method of anaesthesia in the individual group of patients. Concerning circulatory changes, significant variations on 1%- level were found.

Aged↗
PubMed1981

[Sympathetic activity and blood pressure in normotensive and hypertensive patients undergoing ophthalmic surgery under electrostimulation anaesthesia (author's transl)].

Plasma adrenaline, noradrenaline, blood pressure and heart rate were determined in 10 normotensive and 10 hypertensive patients undergoing ophthalmic surgery under electrostimulation anaesthesia. Venous blood samples for the determination of the catecholamines by a spectrofluorometric method were taken 30 min after premedication and 45 min after surgical incision. The catecholamine concentrations showed no significant differences neither by comparing the normotensive patients with the hypertensive patients nor by comparing the values during operation with them after premedication in each group. However, in the hypertensive patients blood pressure showed a higher increase during operation than in the normotensive patients.

Aged↗
PubMed1980

[Metabolic investigations under electro-stimulation and neurolept anaesthesia (author's transl)].

During ophthalmic operations the effects of electrostimulation anaesthesia on metabolites, as glucose, glycerol, ketone bodies, and on blood gas and acid base parameters, were investigated in 10 patients with normal circulation and metabolism. They were compared with those of a group operated under neuroleptanesthesia. Both groups of patients were treated with muscle relaxation and controlled normoventilation by a N2O/O2 (1:1) mixture. As the determined parameters gave no evidence of significant differences between the two groups, it is concluded that electrostimulation anaesthesia and neuroleptanaesthesia produce comparable analgesia.

Blood Glucose↗
PubMed1979

[The effect of premedication with thalamonal on the plasma catecholamine levels (author's transl)].

The sympathetic suppressant properties of Thalamonal as a premedication is reported in both normotensive and hypertensive patients. The investigations were carried out in 27 patients altogether, of whom 7 were previously treated hypertensives. The plasma catecholamines noradrenaline and adrenaline, the blood pressure and heart rate were monitored before and after premedication.

Blood Pressure↗
PubMed1979

[Recommendations for transfusion therapy. Volume substitution, raising oxygen transport capacity and replacement of clotting factors (author's transl)].

The principal aims of whole blood transfusion therapy are simultaneous volume substitution, raising the oxygen transport capacity and the replacement of clotting factors. The necessary control factors for volume substitution are described. It must be borne in mind that the blood undergoes changes during storage which among other things affects the ability of the blood to transport oxygen and the clotting potential. Not only the destruction of thrombocytes must be considered but also the loss of activity of the proaccelerin and the antihemophilic globulin A. For this reason for massive blood transfusions using older blood conserves it is recommended that the loss of activity be compensated by antihemophilic cryoprecipitate.

Biological Transport↗
PubMed1979

[The circulatory system in patients under electrostimulation anaesthesia during ophthalmological operations (author's transl)].

Anaesthesia by electrostimulation and its effects on the circulatory system were investigated in 65 elderly patients, in whom operations on the retina and vitreous body were performed. Stimulation of the dermatomes of the first and second trigeminal nerve as well as of C3 and C4 was performed using stimulating needles in 25 patients and adhesive electrodes in 40 patients. All patients were intubated after injection of thiopentone and a muscle relaxant. Anaesthesia was maintained by continuous electrostimulation, intermittent relaxation and normoventilation with N2O/O2 in a ratio of 1/1. During this anaesthesia technique, marked stability of the circulatory system was observed. This was noted in 32 normotensive and 33 hypertensive patients, the latter being partly under antihypertensive medication. Electrostimulation anaesthesia therefore may be recommended for elderly and high risk patients.

Adult↗
PubMed1979

[Plasma-catecholamines under electrostimulation and neurolept anaesthesia for retina and vitreous body operations (author's transl)].

We determined in two groups of patients with normal circulation and metabolism during operations on the retina and vitreous body the concentration of plasma catecholamines. The intensity of stress was compared between electrostimulation anaesthesia and neuroleptanaesthesia. Venous blood was sampled 1) before premedication, 2) 30' after premedication, 3) at the start of surgery, 4) 45' after the start of surgery, 5) 30' after extubation. Plasma catecholamines (adrenaline and noradrenaline) were determined using a modified trihydroxyindol-spectrofluoremetric method (combined "Batch-technique"). There was no relevant difference between the two techniques of anaesthesia when using the concentrations of plasmacatecholamines as an indicator of stress resulting from operation and anaesthesia.

Acid-Base Equilibrium↗
PubMed1979

[Behaviour of plasma-cortisol during ophthalmological operations in patients under electrostimulation anaesthesia (author's transl)].

Plasma cortisol was determined before, during and after ophthalmological operations. These were performed under electrostimulation anaesthesia using adhesive electrodes attached to the dermatome of the site of operation. Plasma cortisol decreased after premedication and induction of anaesthesia; it increased continuously during surgery beyond the end of operation. Thirty minutes after extubation plasma cortisol decreased again.

Acupuncture Therapy↗
PubMed1979

[Coagulation problems associated with massive blood transfusions. An experimental study (author's transl)].

During storage banked blood show changes as far as function and concentration of their corpuscular and plasmatic ingredients are concerned. Antihaemophilic globulin (factor VIII) and pro-accelerin (factor V) in particular lose their activities so quickly that only very few activities still remain after a storage period of 3-5 days. In connection with existing primary diseases but also in trauma and shock a dilution-coagulopathy caused by insufficient supply of factors VIII and V can develop during massive transfusion, and this especially with banked blood already stored over a longer period of time. Therapy of this disturbance of coagulation consists of substituting the missing coagulation factors under heparin protection.

Blood Coagulation Disorders↗