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Biomedical subjects

W Otto

Publications and source records attributed to W Otto.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Various periodical and aperiodical variations of heart infarct mortality in the DRG].

On the basis of 66.900 cases of death from ischaemic heart disease from 1970 to 1974, patient aged 70 years and younger, total statistics, an average quotient for the house/clinic-relation was calculated. The variations of the house/clinic-relation observed are subdivided into 3 stable periods: 24-hour periodicity, season periodicity and weekday periodicity (socially conditioned). These periods are superimposed by aperiodical influences. The relations between increased house/clinic-relation of the cases of death from ischaemic heart disease and the increased influences of the geomagnetic field as well as geomagnetic tempests (SSC). Here a significant positive connection for the indicators of activity as well as for the SSC was the result. One can issue from the fact that, the higher the ratio is the more unfavourable conditions for a specialised therapy of the complications of the ischaemic heart disease are existing. The cases in question in this phenomenon are new chronobiological knowledges which have a direct relation to the medical practice. Instances are given for the practical use in the prevention of complications of the ischaemic heart disease.

Aged↗
PubMed1982

[Diagnostic criteria and therapy of gout].

Among the diagnostic criteria the proof of urate crystals in the joint fluid is regarded as absolutely specific in the acute gout. In contrast to this the hyperuricaemia as an isolated finding has only a slight diagnostic value. For scientific and clinical proposes 7.0 mg/dl is to be regarded as upper limit value of the serum uric acid for the two sexes together. The chronic primary gout may with the help of the clearance of uric acid, the daily excretion of the quantity of uric acid as well as the pH-measurement of the urine pathogenetically be differentiated into a type of overproduction (type I about 20%) and into a type of renal excretion (type II about 80%), from which therapeutic consequences are the result. By dispensary care of the chronic form of the course we succeed, as a rule, in avoiding severe organic lesions at the kidney.

Acute Disease↗
PubMed1982

[Synovial milieu in gouty arthritis].

The synovial milieu in uric arthritis is characterized with the help of own findings of examinations and data in literature. Apart from the mean values of cytological and biochemical findings of the synovia the changes under therapy are described on the basis of individual examples. The formation of monosodium urate crystals seems to be the starting point of the inflammatory joint process in gout. The size of the arthritic syndrome is among others determined by the local metabolic process, in which case lactate acidosis and reduction of energy as well as the increase of enzyme activities seem to stand in the foreground.

Arthritis↗
PubMed1981

[Comparative biochemical studies in asymptomatic hyperuricemia and manifest gout with special reference to renal change].

It is reported on results of comparative biochemical examinations in asymptomatic hyperuricaemia and manifest gout. Restriction of the urate clearance of the kidney, which could be proved also in young patients with asymptomatic hyperuricaemia, and a disturbance of the lipid metabolism which appeared in most cases are discussed from the pathogenetic point of view, in which cases the hyperlipoproteinaemia is regarded as a possible partial pathogenetic factor. For the separation of serum and urine the polyacrylamide gel-pore gradient electrophoresis was used. Using a modifiable concentration gradient this method is superior to the usual disc electrophoresis. The distribution pattern of the types of haptoglobin established by serum separation showed clear deviations from the normal distribution in hyperuricaemia or manifest gout and may be explained as a reference to the influence of genetic factors. By parallel performed electrophoretic separation of serum and urine a microproteinuria could be established and differentiated between glomerular and tubular proteinuria which is regarded as an early symptom of renal changes and was already present in 9 of 20 young patients with asymptomatic hyperuricaemia. These findings emphasize the necessity of an early renal diagnostics.

Adolescent↗
PubMed1981

[Characteristics of the early phase of ankylosing spondylitis].

100 patients with several clinical and suspicious radiological symptoms of Bechterev's disease (Institute of Rheumatology Moscow) and 100 patients with the clinical symptoms of Bechterev's disease without radiological symptoms of a sacroiliacal arthritis (Medico-Policlinical Institute Leipzig) have been examined within a common research programme since 1976 and analysed concerning the frequency of the complaints as well as of clinical symptoms at the beginning of the disease. The main complaints at the beginning of Bechterev's disease are nocturnal pains in the lumbosacral region, pains in the joints, in which cases 50% of the patients spoke of swellings of the joints. 42% of the patients complained of the feeling of the morning rigidity in the lumbar spinal column and 22% spoke of increased temperatures. In 9--10% of our patients an iritis was diagnosed at the beginning of the disease.

Adolescent↗
PubMed1980

[Early diagnosis and prognosis of ankylosing spondylitis].

The first EDV-evaluations of miltilateral study of countries belonging to the council of mutual economic aid together with the research institutes for rheumatism Moscow, Piestany and Warsaw concerning early diagnostic symptoms of spondylitis ankylosans are discussed. According to this anemnestic data on lumber pains in the second half of the night with morning rigidity, frequently combined with pseudoradicular unilateral irradiations into the thigh (at least 3 months) possess an approximate leading character as prodromi. Other reference signs, such as relapsing iritides, mono-oligo-arthritides as well as the proof of the histocompatibility antigen HLA-B 27 lead to the tentative diagnosis which becomes clinically evident by supervening of functional disturbances of the spine and humoral inflammatory parameters. The definitive diagnosis demands radiological confirmation. Dispensary care with early complex therapy improves the prognosis with regard to an untimely invalidisation.

Diagnosis, Differential↗
PubMed1980

[Functional diagnostics of the adrenal cortex following long term treatment with prednisolone].

Promounced cases of disturbances of the function of the adrenal cortex may more certainly be found out with the help of the enlarged sinacthen test than after a stimulation done only but once. In a long-term prednisolone therapy of 10 mg/a day we could observe signs of disturbances of the function of the adrenal cortex. A clear evidence in the estimation of the individual value is possible only in decreased plasmacortisol levels which are during the whole course of the experiment. When a prednisolone therapy is established for a longer time apart from the sequels at the adrenal cortex should be thought also of the great number of the side effects caused by the catabolic properties of the cortico-steroids.

11-Hydroxycorticosteroids↗
PubMed1979

Some functions of canine liver perfused ex vivo with bloodless fluorocarbon emulsion.

6 canine livers were perfused extracorporeally with bloodless fluorocarbon emulsion for 6 h. Perfusate was oxygenated in vitro with a mixture of oxygen and carbon dioxide. Biochemical studies were performed on the samples of perfusate taken from the arterial and venous lines of the perfusion circuit, and of the bile. Hepatic tissue was sampled prior to and following 6 h of perfusion for histological and biochemical studies. Changes, if any, found in the concentrations of various components of perfusate and bile, were considered due to the metabolic activity of the liver. Moderate changes of the liver architecture and a decrease of glycogen were found in hepatic tissues studied microscopically. Under the conditions of the present preliminary experiment, canine livers remained functional after 6 h of perfusion.

Animals↗
PubMed1978

[Clinical assessment of the activity and results of therapy in joint diseases through cytologic examination of puncture fluids (author's transl)].

Activity and results of therapy of joint diseases can be evaluated by means of cytological examinations of the synovia which is at the same time a prerequisite for differential diagnosis using the puncture fluid. Our cytological examinations of more than 700 puncture fluids stemming from different joint diseases were carried out immediately after the puncture on the fresh material, in order to prevent misinterpretation. This may occur through flaking out in stored material, which results in decrease in the cell count and a non-representative differential cell picture in the supernatant, as well as through degeneration of cells. In two thirds of our patients the local process activity, measured in terms of the cytological phase of activity, became evident in the total clinical activity. The synovia analysis furthermore permits objective assessment of the result of intra-articular injection treatment. Intractable activity, substantiated through synovia examination indicates synovectomy.

Diagnosis, Differential↗
PubMed1977

[Socio-biorhythm of heart-infarct mortality--the subcycle of weekdays].

Examinations of all persons who suddenly on the way died of myocardial infarction who were 70 years old and younger (so-called U-cases) in the GDR from 1970 to 1974 on the basis of certificates of death resulted in a statistically significant different distribution of persons who died on the way to the physician or in the waiting-room (so-called cases U3) compared with persons who suddenly died during transport (so-called cases U4) in 6 town-counties. From the results regional-specific causes of organizational kind in the outpatient public health and at the level of population could be derived as well as conclusions could be made for the secondary prevention by decrease of the socially determined subcycles.

Circadian Rhythm↗
PubMed1977

[Therapy of ankylosing spondylitis].

Due to the unknown etiology of the ankylosing spondylarthritis up to now a causal therapy is not possible. By complex methods of treatment, consisting of chemo- and physiotherapeutic measures we succeed in controlling the course of the disease in as far that the most severe morphological lesions may be prevented. Decisive is the use of a basis therapeutic, in which case chlorochine has been proved favourable. In the last years by optimum dispensary care of these patients with regular controls of the course and controls of the therapy as well as use of all possible rehabilitation measures the premature rate of invalidisation could be reduced from about 50% to 10%. When the disease is recognized in the prodromal phase there exists established hope of preventing severe morphological lesions.

Chloroquine↗
PubMed1977

[Prognostic significance of serum iron level, hemoglobin and rheumatoid factor titre in rheumatoid arthritis].

On the basis of the results of a five-year examination of the course on 120 patients with rheumatoid arthritis the authors adopt a definite attitude to the prognostic significance of hypersiderinaemia, anaemia and height of the titre of the rheumatoid factor. With the help of the chi2-test and the rank correlation after Spearman the statistical relations to stage, activity, clinical and radiological progressing as well as to the number of the affected joints were examined. In seropositive patients we found a correlation of the titre of rheumatoid factor and stage. Furthermore a clear correlation existed to clinical and radiological progressing as well as to the number of the affected joints. Early highly positive titres of the rheumatoid factor as an expression of high immunologic activity suggest an unfavourable prognosis in the majority of cases. Constant anaemia and hyposiderinaemia as symptoms of a high basis activity of the disease also showed close relations to the progressing. From this result indications for the early use of important therapeutic measures. For the prognostic judgement of the course of the disease of rheumatoid arthritis it is necessary to have at disposal further methodically simply determinable parameters for the recognition of the basis activity and the immunologic activity.

Anemia, Hypochromic↗