PubMed Health⌕ Search

Biomedical subjects

W Rösch

Publications and source records attributed to W Rösch.

At least 109 records · Page 6Linked to original sources
PubMed1987

Cisapride in non-ulcer dyspepsia. Results of a placebo-controlled trial.

The effect of cisapride, 10 mg three times daily, was evaluated in a double-blind randomized study in 118 patients with non-ulcer dyspepsia. Peptic ulcer disease was excluded by endoscopy, gallstones by ultrasonography, and chronic pancreatitis by a series of non-invasive tests. Symptomatic improvement was evaluated by interview after 2 and 4 weeks; the patients also kept a diary. Cisapride caused significant improvement compared with placebo with regard to frequency and severity of symptoms and may therefore be useful in the therapy of non-ulcer dyspepsia.

Cisapride↗
PubMed1987

[Therapy of peptic ulcer and chronic gastritis with bismuth salts].

Colloidal bismuth subcitrate (CBS) precipitates in an acid environment, adheres to mucus, blocks pepsin activity, retards hydrogen-ion back diffusion and stimulates prostaglandin synthesis. The average healing rate after 4 weeks' treatment with CBS is 78% in duodenal ulcer versus 67% with cimetidine. A direct comparison with ranitidine gives healing rates of 78% (CBS) as opposed to 78% with ranitidine. The corresponding figures in gastric ulcer are 68% (CBS) and 54% (cimetidine). The percentage of relapse-free patients is substantially higher after CBS ulcer healing than after H2-blockers. Bismuth subsalicylate eliminates Campylobacter pylori in 71% after 4-weeks' therapy. Parallel to this elimination a decrease and normalization of the acute inflammatory process can be seen in antral mucosa.

Anti-Ulcer Agents↗
PubMed1986

[Study of the correlation of sonographic and scintigraphic results in measuring stomach emptying].

"Stomach cockade" can be readily imaged sonographically, so that it has also been possible to carry out studies of gastric motility or measurements of gastric emptying times of fluids. However, the results of measurements should be verified by reference methods using new investigation techniques. For this reason, we measured synchronously by sonography and scintigraphy the emptying of test fluids from the stomach in patients with diabetes mellitus and suspected gastroparesis. We found a correlation of the two methods of measurement, so that sonographic measurement can be regarded as confirmed by scintigraphy as a reference method.

Adult↗
PubMed1986

Treatment of duodenal ulcer with low-dose antacids.

The aim of the present investigation was to compare the efficacy of a low-dose antacid (Maalox 70, 280 mmol/day) with that of the H2-receptor antagonist cimetidine (Tagamet, 200 mg three times daily and 400 mg/day) after 14 and 28 days in the treatment of duodenal ulcer. The prospective multicentre study included 171 patients with endoscopically confirmed duodenal ulcers. The patients were randomly assigned to the treatment groups with antacid containing Mg and Al hydroxide (M)(4 X 70 mmol/day; n = 86) or to the group receiving cimetidine (T) (1000 mg/day; n = 85). The two treatment groups were matched for age, sex, drinking and smoking habits, and drug use. Endoscopic examinations were carried out before the start of treatment and 14 days later. If the ulcer was still present at this time, the second endoscopic examination was done after a further 14 days. Endoscopically, the ulcer had healed at 14 days in 38.8% (M) and in 34.9% (T) and at 28 days in 80.0% (M) and 74.7% (T), respectively. The healing rate did not differ significantly between the two treatment groups. Complaints, measured as percentage of days per week with upper abdominal pain, were significantly reduced in both groups. No significant differences were found between the two treatment groups with regard to pain relief or side effects. Treatment had to be abandoned in one patient receiving antacid because of diarrhoea and in one patient receiving cimetidine because of the absence of any response.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1986

The treatment of chronic recurrent pancreatitis with depot secretin--a preliminary report.

Increased viscosity and raised lactoferrin, trypsin and protein concentrations in selectively aspirated pancreatic secretion, prompted us to try depot secretin therapy in patients with advanced chronic recurrent pancreatitis without pancreatic duct obstruction or pancreatic pseudocysts. The idea behind this approach was that it might "wash out" the sticky, protease-rich secretion. In a randomized double-blind trial we administered depot secretin at doses of 800 CU by subcutaneous injection twice daily for 7 days. Pancreatic secretion from the treatment group had significantly lower viscosities and lactoferrin and trypsin concentrations than in the placebo group. There was also significant pain relief. Depot secretin therapy appears to offer an alternative approach to the management of advanced chronic recurrent pancreatitis without pancreatic duct obstruction or pseudocysts.

Amylases↗
PubMed1985

[Prevention and therapy of acute gastrointestinal hemorrhage].

85% of all gastrointestinal bleeding occurs in the upper gastrointestinal tract. For this reason prophylactic and therapeutic efforts concentrate on the esophagus, stomach and duodenum. Prophylaxis of stress ulcers with H2-blockers and, in some specially endangered patients, with a combination treatment is well accepted. In regard to therapy of bleeding complications, however, medical and surgical treatment procedures compete. Stopping the bleeding during diagnostic endoscopy has gained considerable importance. Success depends - just as does success of pharmacotherapy - upon intensity of bleeding and morphology of the bleeding source (Forrest criteria). For prophylaxis of bleeding relapses from peptic lesions H2-blockers in combination with antacids or pirenzepine are treatment of choice.

Duodenal Ulcer↗
PubMed1984

[Long term management of peptic ulcer. Indications and side effects of drug therapy compared with surgical procedure].

Long-term drug therapy of peptic ulcers may be practiced using cimetidine, ranitidine, sucralfate or possibly pirenzepine, but H2-blockers are considered to be the best treatment. Whereas in Zollinger Ellison syndrome and in stomal ulcers maintenance therapy is mandatory, the indications in uncomplicated ulcer disease are not yet established. 2 or 3 recurrencies per year, previous complications or high-risk conditions can be discussed, however, every patient should be informed of the surgical alternative since recurrence rate of long-term treatment exceeds the surgical approach.

Aluminum↗