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Biomedical subjects

W W Tryon

Publications and source records attributed to W W Tryon.

At least 19 recordsLinked to original sources

Activity measurements support dimensional assessment.

The Diagnostic and Statistical Manual approach to motor excess has been to treat it as a categorical variable whose presence functions as an inclusion criterion. Motor excess is thought to occur primarily during structured settings that maximize attentional demands. Activity is rarely measured as a dimensional attribute despite availability of a wide variety of suitable instruments for more than a decade (Tryon, 1985). The present study measured activity using electronic step counters in structured and unstructured school settings, commuting from home to school and back home, and at home for 2 consecutive weeks in 60 children selected from 450 children using Factor IV (hyperactivity) scores from the Conners Teacher Rating Scale to represent three levels of hyperactivity. Results indicate that (a) children rated as hyperactive are measurably more active than children rated as normally active in unstructured as well as structured situations, (b) measured activity correlates consistently and substantially with rated activity in unstructured and structured situations, and (c) a single activity factor characterizes measured activity in all situations except for class transitions during school. These results and other published findings support a quantitative (dimensional) rather than qualitative (categorical) approach to motor excess.

Attention

Synthesizing animal and human behavior research via neural network learning theory.

Animal and human research have been "divorced" since approximately 1968. Several recent articles have tried to persuade behavior therapists of the merits of animal research. Three reasons are given concerning why disinterest in animal research is so widespread: (1) functional explanations are given for animals, and cognitive explanations are given for humans; (2) serial symbol manipulating models are used to explain human behavior; and (3) human learning was assumed, thereby removing it as something to be explained. Brain-inspired connectionist neural networks, collectively referred to as neural network learning theory (NNLT), are briefly described, and a spectrum of their accomplishments from simple conditioning through speech is outlined. Five benefits that behavior therapists can derive from NNLT are described. They include (a) enhanced professional identity derived from a comprehensive learning theory, (b) improved interdisciplinary collaboration both clinically and scientifically, (c) renewed perceived relevance of animal research, (d) access to plausible proximal causal mechanisms capable of explaining operant conditioning, and (e) an inherently developmental perspective.

Animals

Psychomotor retardation found in college students seeking counseling.

Psychomotor retardation (PMR) has been documented for inpatient populations. Futterman and Tryon (1994) [Journal of Behavior Therapy and Experimental Psychiatry, 25, 41-48] provided the first report of PMR in a female outpatient sample. Because 8 of their 11 depressed Ss were receiving medication, the possibility remains that Futterman and Tryon's findings were due to medication side effects. The present study documents PMR in a nonmedicated male and female college population. Two-week, 24-h per day, content-valid behavioral measurements were obtained using step-counters from 73 college students seeking counseling. The 20 males and 53 females completed the Inventory to Diagnose Depression, the State-Trait Anxiety Inventory, the Marlowe-Crowne Social Desirability Inventory, and a structured interview. Regression analysis revealed that depression was negatively related to daytime activity. Significant age and gender effects were statistically controlled.

Adolescent

Psychomotor retardation found in depressed outpatient women.

Psychomotor retardation (PMR) has been found consistently in depressed inpatients. This article is the first to report PMR in depressed women outpatients in contrast to matched nondepressed controls, despite heterogeneous differences in lifestyle, using 2-week content-valid behavioral measurement. Principal findings include significant and substantial daytime activity reduction not explained by seven covariates. The absence of significant nighttime difference is explained on the basis of instrumentation limits.

Activities of Daily Living

Estimating and testing autocorrelation with small samples: a comparison of the C-statistic to a modified estimator.

Huitema and McKean (Psychological Bulletin, 110, 291-304, 1991) recently showed, in a Monte-Carlo study, that five conventional estimators of first-order autocorrelation perform poorly for small (< 50) sample sizes. They suggested a modified estimator and a test for autocorrelation. We examine an estimator not considered by Huitema and McKean: the C-statistic (Young, Annals of Mathematical Statistics, 12, 293-300, 1941). A Monte-Carlo study of the small sample properties of the C-statistic shows that it performs as well or better than the modified estimator suggested by Huitema and McKean (1991). The C-statistic is also shown to be closely related to the d-statistic of the widely used Durbin-Watson test.

Biometry

The role of motor excess and instrumented activity measurement in attention deficit hyperactivity disorder.

Motor excess was once recognized as a primary aspect of childhood behavior disorder but has been largely discounted by current investigators despite consistent reference to hyperactivity in titles of articles, chapters, and books. The presumed minor relevance of hyperactivity to attention deficit hyperactivity disorder (ADHD) is based on analogue assessment procedures that remain to be validated. Results of content-valid instrumented behavioral measurements show that ADHD children are pervasively hyperactive. These findings are consistent with recent research showing activity to be an important aspect of temperament and a well-documented factor of externalizing disorders of childhood. Theoretical analyses of the relationship between hyperactivity and ADHD disorder are presented.

Adolescent

Issues of validity in the Diagnostic Interview Schedule.

The Diagnostic Interview Schedule, the chief instrument in contemporary studies in psychiatric epidemiology, enhances the reliability of psychiatric diagnosis and enables lay interviewers to closely reproduce psychiatric interviews. However, despite frequent references in the literature to the validity of the Diagnostic Interview Schedule, most studies fundamentally represent variations of reliability paradigms to the neglect of criterion-related validity. Mistaken assertions of validity persist in the psychometric language used to describe the Diagnostic Interview Schedule. This article examines the basis for claims and counterclaims of validity in accordance with standard psychometric definition, and identifies sources of erroneous reasoning in attempts to infer validity from reliability. The article presents a general framework organizing the process of diagnostic validation and discusses strategies for research seeking to validate psychiatric diagnoses achieved through the Diagnostic Interview Schedule.

Humans

Activity decreases as percentage overweight increases.

The purpose of the present research was to clarify the empirical relationship between percentage overweight and degree of ambulatory activity. Two week activity measurements were obtained, over two studies, using pedometers, from 127 women aged 19 to 55 years ranging from 14% underweight to 99% overweight. Regression analysis indicated that activity decreased by 7.6457 x 10(-4) mph for every 1% increase in percentage overweight from 0.25279 mph associated with zero percentage overweight. These data are in good agreement with data published by Chirico and Stunkard in 1960.16 Implications for small activity increases on obesity and general health are discussed.

Adult

Evaluation of mental health. Issues of memory in the Diagnostic Interview Schedule.

Research on the Diagnostic Interview Schedule, the chief instrument in contemporary studies in psychiatric epidemiology, has supported its utility in enabling lay interviewers to reproduce psychiatric interviews within an acceptable margin of error. Nonetheless, we propose that the Diagnostic Interview Schedule commits itself to dubious assumptions regarding the accuracy of human memory, shared by other history-taking efforts, by relying on retrospective reports of lifetime DSM-III symptoms and episodic dating of symptom spells. For more than a century, the fallibility of human memory has been the topic of intensive experimental and naturalistic study, a history which is relevant to the construction of instruments like the Diagnostic Interview Schedule. The continuing use of retrospective lifetime symptom reports suggests that this literature has been largely ignored in the development and administration of the Diagnostic Interview Schedule. Prospectively organized research is needed to disclose the limits of human memory for recent psychiatric events and the mediating conditions under which memory for such events can be accurately retrieved and improved.

Adult

Classical conditioning of meaning--II. A replication and triplet associative extension.

The meaning associated with verbal stimuli is modifiable by classical conditioning, suggesting that such "language conditioning" may be used clinically to modify a client's maladaptive associative history. The current research investigated the existence and generalizability of this phenomenon by attempting to replicate Staats and Staats' (1957) language conditioning effect and then extend it to a triplet conditioning paradigm (CS2----CS1----UCS). Previous research by the current authors replicated language conditioning, yet failed to extend it to a higher-order situation. Significant conditioning was obtained to the CS1, particularly for aware subjects, but no conditioning occurred to the CS2. Implications for verbal conditioning theory and clinical practice are discussed.

Adult

Classical conditioning of meaning--I. A replication and higher-order extension.

The meaning that individuals associate with verbal stimuli may be modified by using classical conditioning procedures. Clinically, such procedures may be used to modify a client's maladaptive associations. The current research investigated the existence and generalizability of this phenomenon by attempting to replicate Staats and Staats' (1957) language conditioning effect and then extent it to a second-order classical conditioning situation (CS1----UCS then CS2----CS1). Such higher-order conditioning would suggest that several different but related maladaptive associations can be modified simultaneously. Significant conditioning was obtained to the CS1, particularly for aware subjects, but no conditioning occurred to the CS2.

Adult

Study of the similar structure hypothesis with mentally retarded adults and nonretarded children of comparable mental age.

The similar structure hypothesis was tested by comparing the performance of mentally retarded adults and their nonretarded mental age peers on a series of Piagetian tasks. We controlled for variables that influence the testing of mentally retarded subjects and performance on Piagetian tasks. Statistical analysis revealed that five tests favored the developmental position whereas two tests favored the difference position. Qualitative analysis provided reason to question the validity of two of the seven tests. Nevertheless, the evidence still favored the developmental position 4:1. Corollaries challenged the use of vocabulary tests for matching and raised a caveat concerning the acquisition by mentally retarded adults of key concrete operations skills.

Adult

The effectiveness of biofeedback-assisted relaxation in modifying sickle cell crises.

Eight outpatients with sickle cell disease received six EMG and six thermal half-hour biofeedback training sessions. Statistically significant changes in the desired directions were obtained for the following variables: (a) frontalis muscle tension, (b) digital temperature, (c) frequency of headache as a crisis symptom, (d) frequency of analgesic use, (e) perceived pain intensity, (f) frequency of self-treated crises, and (g) state anxiety. Nonsignificant changes in hospital chart data were found. A 6-month posttreatment follow-up questionnaire revealed the continued effectiveness of the training received regarding headaches and mild pains.

Adolescent

Activity as a function of body weight.

Thirty-one undergraduate men and women who weighed more (overweight) or who weighed less (underweight) than the normal weight limits for their height wore actometers on all four limbs 24 h each day for 14 consecutive days. All groups were found to be equally active. This result fails to replicate previously reported results that overweight men and women are hypoactive. This discrepancy is explained in terms of differences in percent overweight between the present and previous samples. The possibility of a catastrophic decline in activity as a function of percent overweight is discussed.

Adult

Accelerometric assessment of tardive dyskinesia.

Accelerometric measures associated with resting the hand, posturing the arm, and moving the arm were taken in 10 patients with tardive dyskinesia and eight schizophrenic patients matched for diagnosis, age, sex, likelihood of medication to induce extrapyramidal symptoms, and chlorpromazine-equivalent dose. A multivariate analysis of variance and follow-up univariate analyses revealed that the tardive dyskinesia patients showed 1) greater amplitude of dyskinetic movements, 2) lower peak frequency of dyskinetic movements, and 3) more spikes-points beyond four standard deviations from the mean. Multiple discriminant analyses revealed that all patients were correctly classified as to presence or absence of tardive dyskinesia.

Antipsychotic Agents

Periodontal disease as a function of life events stress.

Studies relating stress and oral pathology have been limited to animal experiments or clinical studies of personality and psychological health that have ignored the role of specific life events. The present study related measurements of life events stress to measurements of periodontal disease. Subjects were fifty male volunteers recruited from a pool of dental patients from the Brooklyn VA Outpatient Dental Clinic. Oral examinations were given to determine the degree of periodontitis and gingivitis. Evidence of other somatic symptomatology was assessed by the somatization subscale of the Brief Symptom Inventory. The degree of life events stress was assessed with the Life Experience Survey. Measurements of life events stress were found to be significantly correlated with measures of periodontal disease. Periodontal disease was more severe and widespread as stressors increased. Subjects were found whose general physical health was unrelated to their life situation.

Adult

Activity measures in anorexia nervosa.

Twenty-four-hour measurements of wrist and ankle kinetic energy expenditures were obtained on 20 hospitalized female anorectics during the first two weeks of their hospitalization. Kinetic energy was examined against measures of weight, depression, and Minnesota Multiphasic Personality Inventory scores in a regression analysis. Effect of cyproheptadine hydrochloride, amitriptyline hydrochloride, and placebo on activity was assessed. The results supported previous studies showing a positive relationship between weight gain and motor activity and challenge the commonly held notion that activity decreases in anorectics as their clinical condition improves. Motor activity was initially significantly suppressed by cyproheptadine and subsequently increased.

Adolescent