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Biomedical subjects

Y Hisa

Publications and source records attributed to Y Hisa.

At least 55 records · Page 3Linked to original sources
PubMed1992

[Adenoid cystic carcinoma of the head and neck: a clinical review of 29 cases].

Pathological data and the outcomes of 29 patients with adenoid cystic carcinoma of the head and neck treated between 1975 and 1990 were reviewed. Patients consisted of 21 females and 8 males, with a median age of 59 years. The overall 5-year and 10-year survival rates determined by Kaplan-Meier analysis were 84.2% and 52.9%, respectively. Patients in whom pathological data indicated a frequent solid pattern of carcinoma had high incidences of metastasis and poor prognoses. The effectiveness of local control was found to have no relation to the pathological data of the tumor, but rather depended upon whether anatomical limitations restricted complete resection of the tumor. All 7 patients who had cervical lymph node metastasis underwent neck dissection, which was useful in controlling metastatic spread. Distant metastases were present in 6 patients, and the lung was the most frequent site of metastasis.

Adult↗
PubMed1991

Localization of the sensory neurons in the canine nodose ganglion sending fibers into the internal branch of the superior laryngeal nerve.

The distinct localization of the sensory neurons in the canine nodose ganglion that send fibers into the internal branch of the superior laryngeal nerve (the main sensory pathway from the larynx) was studied using horseradish peroxidase technique. The labeled cells were located mainly in the rostral one-third of the lateral side of the nodose ganglion. We conclude that the localization of these labeled cells does not reflect a difference in cellular role or function but is due to the course of the nerve's fibers.

Animals↗
PubMed1990

Quantitative histochemical studies on the cat infrahyoid muscles.

The intrinsic laryngeal muscles have been reported to be composed of muscle fibers that have unusual physiologic, morphologic, and biochemical characteristics, and it has been suggested that the relatively unique differentiation of these muscle fibers is the result of their specific activity patterns. Because the infrahyoid muscles are recruited for some of the same laryngeal functions, it was of interest to determine if they also included unusual fiber types. In order to examine this possibility, microdensitometry was carried out on type I, type IIA, and type IIB fibers in the cat sternohyoid, sternothyroid, and thyrohyoid muscles using histochemical techniques for a variety of enzymatic markers of oxidative and glycolytic capacity and for fiber size. It was found that the infrahyoid muscles were composed of muscle fibers having enzyme profiles generally similar to those of fiber types in the limb muscles.

Adenosine Triphosphatases↗
PubMed1990

[Prognostic significance of the DNA ploidy of the early glottic cancer].

The stage classification is most frequently used at the present in predicting the outcome of laryngeal carcinoma. Recently, DNA ploidy pattern as detected by DNA flow cytometry and cytofluorometry has been also shown to be predictive. In this study, DNA cytofluorometry was performed on formalin-fixed paraffin-embedded tissues from 18 patients with T1 and T2 glottic squamous cell carcinoma for whom long-term follow-up data were available. The DNA ploidy pattern was classified into three types, diploid, diploid + tetraploid and aneuploid according to the DNA content of Go/G1 cells and mitotic cells. In these 18 cases, 8 cases (44%) had diploid pattern, 3 cases (17%) had the diploid + tetraploid pattern and 7 cases (39%) had the aneuploid pattern. The ploidy pattern was significantly associated with the relapse-free rate, but did not correlate with the stage of the carcinoma and differentiation of the cancer cells. Distribution of the patients by histology, stage and therapy was almost equal among the diploid, diploid + tetraploid and aneuploid groups. All the patients were treated with irradiation (60Gy). In the group as a whole, no patient died of glottic carcinoma. Relapse-free survival rates for diploid, diploid + tetraploid and aneupoid were 88%, 33% and 29% respectively. This retrospective study of glottic cancer treated with radiation therapy suggests the possibility that the DNA ploidy pattern would significantly predict patient outcome and would be useful for selecting patients whose poor prognosis demands more aggressive therapy.

Aged↗
PubMed1989

Actomyosin adenosine triphosphatase activities of the cat infrahyoid muscles.

By use of actomyosin ATPase histochemistry, it was found that there were large differences among the three cat infrahyoid muscles (sternohyoid, sternothyroid, and thyrohyoid) with respect to their percentages of different muscle fiber types. It has been established that the individual activity patterns of the component motor units in each muscle drive the biochemical and physiologic differentiation of the muscle fibers associated with each motor unit. Therefore, the data obtained in the present investigation provide an indication of the characteristics of long-term use of each of the various types of motor units, as well as the associated differences in the physiologic capacities of the different motor unit types composing each of these infrahyoid muscles.

Animals↗
PubMed1989

[A case of congenital laryngeal web with subglottic stenosis].

A severe case of congenital laryngeal web with subglottic stenosis was reported. The patient had weak crying after birth and stridor was noticed from one month old. He had tracheostomy at two month old and the incision of the web was attempted under laryngomicrosurgery with CO2 LASER, although the attempt failed due to combined subglottic stenosis. The "trough method" was applied at the age of one year. The web was incised and subglottic granulation including the excessive cartilaginous tissue was removed through a laryngotracheal fissure. A piece of silicone membrane was inserted between the vocal cords preventing from adhesion and a silicone tube stent was also inserted into the subglottic space and trachea to keep the laryngotracheal space open widely. After one month and a half, the silicon membrane and silicon tube were removed and a silicon T-tube was inserted instead of the silicon tube. The anterior wall of the laryngotracheal space was closed using a hinge flap. The patient can vocalize and does not complain of dyspnea at present, one year after the removal of the T-tube.

Humans↗
PubMed1989

[Nuclear DNA cytofluorometry of normal human laryngeal epithelia and squamous cell carcinoma].

Normal human laryngeal epithelia and laryngeal squamous cell carcinoma were assayed by Feulgen DNA cytofluorometry using free cell nuclei isolated from carnoy-fixed, paraffin-embedded specimens. In all of the 12 normal specimens, the epithelium showed typical diploid cell clones with low proliferative activity. Polyploid cells were seen in only two specimens from subjects aged 61 and 69 years respectively, and the number of polyploid cells seen in these two specimens was only two. Fifteen cancer cases were divided into three groups: an untreated group (5 cases), a chemotherapy group (5 cases) and a group of cases with recurrence after radiation therapy (5 cases). Among these three groups the DNA ploidy patterns were compared. In the untreated group, all cases showed a two-peak diploid pattern and a high proliferative activity, and polyploid cells were present. In the chemotherapy group, a wide one-peak histogram extending from 2C to about 5C was noted in 4 cases, and an aneuploid pattern in one case. Thus, the DNA ploidy pattern in the chemotherapy group differed from that in the untreated group. Of the 5 cases with recurrence after radiation therapy, one had a tetraploid pattern, but the remaining 4, a two-peak diploid pattern similar to that seen in the untreated group. Polyploid cells were observed in all these cancer cases. However, because they were also seen in some normal subjects, the finding of polyploid cells is not considered to be conclusive of cancer diagnosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1989

[A case of adenocarcinoma of the nasal cavity associated with syndrome of inappropriate secretion of antidiuretic hormone(SIADH)].

An inappropriate antidiuretic hormone secretion (SIADH) has been recognized as the cause of hypotonic hyponatremia, and the occurrence of this syndrome, accompanied by an ADH-producing adenocarcinoma in the nasal cavity, is reported. In February, 1987, a 50-year-old male, showing sights of delirium, disorientation, and irritability was admitted to the hospital. The patient was observed to be healthy, except for a neck lymphnode metastasis that was present up to the time of his hospitalization. The hyponatremia was incidentally found, although dehydration or intravascular volume depletion were not noted. These neuropsychiatric symptoms were considered to be associated with hyponatremia due to SIADH. He had had a partial maxillectomy, a neck dissection, and irradiation to the nose and nasal cavity 32 months earlier, and then underwent a surgical resection of the neck metastasis; he had a total of 10 other operations before the onset of the symptoms. Upon initial inspection, since neither an intracranial invasion nor a brain metastasis was found, we diagnosed that his symptoms were due to an autonomic disturbance caused by surgical and mental "stress". When he died of cardiac failure due to a mediastinal invasion 8 months after the onset of SIADH, tumor tissues was extirpated in an autopsy and was then cultured. In this manner, it was proved that the tumor cells had been producing ADH. This procedure clarified that the syndrome had resulted from an ADH-producing tumor of the nasal cavity.

Adenocarcinoma↗
PubMed1986

[Obstetric factors associated with intracranial hemorrhage (ICH) in premature infants and antenatal prediction of ICH].

Obstetric factors associated with intracranial hemorrhage (ICH) were evaluated in 98 inborn premature infants of less than 1,500 gm birth weight or less than 32 weeks of gestation. ICH was detected in 25 (25.5%) of these infants by ultrasound sonography and/or computed tomography. No association of obstetric factors such as maternal age, parity, gravidity, premature rupture of the membrane, toxemia, placenta previa, fetal position, mode of delivery or fetal sex with ICH was noted. But the ICH group showed a higher incidence of placental abruption, infarction, infection and incompetent cervix than the non-ICH group. In addition, gestational ages and birth weights were less in the ICH group than in the non-ICH group, although differences were not significant except for the group with incompetent cervix (p less than 0.05). However, Apgar scores and FHR scores according to Krebs et al. for the ICH group were significantly lower than those for the non-ICH group. The two groups were distinguished by multivariable discriminant analysis of FHR scores, birth weights and gestational ages (discriminant efficiency, 3.74: F-value, 20.6: true positive ratio, 81.3%). These results suggested that antenatal prediction of ICH in premature infants was possible, but further studies are needed to elucidate the reliability of its prediction.

Adult↗
PubMed1985

Central projection of the sensory component of the rat recurrent laryngeal nerve.

The central projection from the sensory components in the rat recurrent laryngeal nerve was studied using WGA-HRP. Sensory terminals were found bilaterally in the nuclei of the tractus solitarius, although they were very sparse contralaterally. In the ipsilateral nucleus, most of these terminals were located in the interstitial subnucleus extending, from the most rostral area, near the obex, caudally for a distance of 1.5 mm.

Animals↗
PubMed1984

The localization of motoneurons innervating the canine pharyngeal constrictor muscles in the posterior larynx by the fluorescent double-labeling technique.

The localization of motoneurons innervating the canine pharyngeal constrictor muscles in the posterior larynx, i.e., the hyopharyngeal muscle (HP), the thyropharyngeal muscle (TP) and the cricopharyngeal muscle (CP), was investigated by the fluorescent labeling technique. Labeled cells were found in the rostral portion of the ipsilateral nucleus ambiguus. The rostral ends of these cell columns were located at nearly the same level. The caudal ends of the HP cell column and the TP cell column were also located at nearly the same level. However, the CP cell column was elongated a little more caudally. The HP cells and the TP cells were intermingled in the dorsal part of the nucleus. The CP cells were mainly located in the ventral part of the nucleus. No double-labeled cells were detected.

Animals↗
PubMed1984

Nucleus ambiguus motoneurons innervating the canine intrinsic laryngeal muscles by the fluorescent labeling technique.

The localization of motoneurons innervating the canine intrinsic laryngeal muscles was investigated by the fluorescent labeling technique. Labeled cells were found in the ipsilateral nucleus ambiguus. The most rostral labeled neurons for the cricothyroid muscle, the posterior cricoarytenoid muscle, the thyroarytenoid muscle, and the lateral cricoarytenoid muscle were found at progressively more caudal levels, respectively, within the nucleus ambiguus. The rostral tip of the arytenoid muscle cell column was at the same level as the lateral cricoarytenoid muscle cell column. The cells labeled from the cricothyroid muscle occupied the ventral part of the nucleus at the rostral level of the nucleus. At the middle level of the nucleus, the cells from the posterior cricoarytenoid muscle occupied the ventral part of the nucleus and the cells from the thyroarytenoid muscle, the lateral cricoarytenoid muscle and the arytenoid muscle occupied the dorsal part of the nucleus. The existence of double-labeled cells which innervated both thyroarytenoid muscle and lateral cricoarytenoid muscle was detected.

Animals↗
PubMed1982

The localization of the motor neurons innervating the cricothyroid muscle in the adult dog by the fluorescent retrograde axonal labeling technique.

Injection of 4'6-diamidino-2-phenylindol 2 HCl (DAPI) into the cricothyroid muscle of the adult dog resulted in blue fluorescence of cells found exclusively in the rostral part of the ipsilateral nucleus ambiguus. These labeled neurons on the average extended 1.8 mm from the level just caudal the facial nucleus to the caudal extension. In the rostral tip of the nucleus, labeled cells were located in a scattered ventral group of larger neurons of the nucleus.

Animals↗
PubMed1982

Fluorescence histochemical studies on the noradrenergic innervation of the canine larynx.

The origin and course of noradrenergic nerve fibers contained in laryngeal nerves and their destinations in the larynx of the dog were investigated using fluorescence histochemistry. The superior laryngeal nerve, including the internal and external branches and the recurrent laryngeal nerve were found to contain many noradrenergic nerve fibers and these laryngeal nerves were the only noradrenergic nerve supply channels for the larynx. The superior laryngeal nerve received noradrenergic nerve fibers from the superior cervical ganglion below the nodose ganglion. The recurrent laryngeal nerve is considered to receive noradrenergic nerve fibers originating from the middle cervical ganglion directly, and those originating from the superior cervical ganglion via the vagus nerve. The cricothyroid muscle received noradrenergic nerve fibers from the external branch of the superior laryngeal nerve and other intrinsic muscles received them from the internal branch of the superior laryngeal nerve and the recurrent laryngeal nerve. The submucosal glands in the supraglottic and epiglottic regions received the noradrenergic nerve fibers from the internal branch of the superior laryngeal nerve and those in the subglottic region were innervated by noradrenergic nerve fibers in the recurrent laryngeal nerve.

Adrenergic Fibers↗