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Development and in vitro evaluation of buccoadhesive tablets using a new model substrate for bioadhesion measures: the eggshell membrane.

B Parodi·E Russo·P Gatti·S Cafaggi·G Bignardi
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Abstract

For oral delivery of antimicrobial and anti-inflammatory drug, mucoadhesive tablets based on gelatin/hydroxypropylcellulose (HPC), gelatin/hydroxypropylmethyl-cellulose (HPMC), and gelatin/sodium carboxymethylcellulose (NaCMC) at different ratios were prepared by direct compression of the mixed powders. Metronidazole and benzydamine were used as model drugs. The in vitro bioadhesive properties, evaluated by a commercial tensile tester, were significantly affected by the model substrate employed, that is, a polypropylene (PP) membrane or a biological membrane (eggshell membrane). The use of the biological substrate seemed to supply more reliable data. All studied formulations showed an erosion-diffusion mechanism of release, anomalous or non-Fickian release, in agreement with the behavior of the swellable systems.

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Administration, OralAnimalsBenzydamineCarboxymethylcellulose SodiumCelluloseChickensDiffusionDrug CompoundingEgg ShellExcipientsGelatinLactoseMembranesMethylcelluloseMetronidazoleMouth MucosaOxazinesPowdersTabletsTensile StrengthTissue AdhesivesJournal ArticleResearch Support, Non-U.S. Gov't

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B Parodi, E Russo, P Gatti, S Cafaggi, G Bignardi. 1999. Development and in vitro evaluation of buccoadhesive tablets using a new model substrate for bioadhesion measures: the eggshell membrane.. https://doi.org/10.1081/ddc-100102173

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