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Osseointegrated implants in irradiated bone: a case-controlled study using adjunctive hyperbaric oxygen therapy.

G Granström·A Tjellström·P I Brånemark
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Abstract

PURPOSE: The current investigation was undertaken to study whether osseointegration of implants in irradiated tissues is subject to a higher failure rate than in nonirradiated tissues. It further aimed to study whether hyperbaric oxygen treatment (HBO) can be used to reduce implant failure. PATIENTS AND METHODS: Seventy-eight cancer patients who were rehabilitated using osseointegrated implants between 1981 and 1997 were investigated. Three groups of patients were compared: irradiated (A), nonirradiated (B), and irradiated and HBO-treated (C). In addition, 10 irradiated patients who had lost most of their implants received new ones after HBO treatment. These were compared as a case-control group. RESULTS: Implant failures were highest in group A (53.7%). Implant failure was 13.5% in group B and 8.1% in group C. The difference between group A and the other two groups was statistically significant (P = .001 to .0023, Mantell's test). HBO significantly improved implant survival in the case-control group from 34 of 43 implants lost to 5 of 42 lost (P = .0078). CONCLUSIONS: Implant insertion in irradiated bone is associated with a higher failure rate. Adjuvant HBO treatment can reduce the failures.

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AdultAgedAged, 80 and overCase-Control StudiesCobalt RadioisotopesDental Implantation, EndosseousDental Restoration FailureFemaleFollow-Up StudiesHead and Neck NeoplasmsHumansHyperbaric OxygenationMaleMiddle AgedNoseOrbitOrthognathic Surgical ProceduresOsseointegrationProstheses and ImplantsProsthesis FailureRadiopharmaceuticalsRadiotherapy DosageSkullTemporal BoneTreatment OutcomeComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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G Granström, A Tjellström, P I Brånemark. 1999. Osseointegrated implants in irradiated bone: a case-controlled study using adjunctive hyperbaric oxygen therapy.. https://doi.org/10.1016/s0278-2391(99)90059-9

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