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PubMed · 10429975

Local low-dose IL-2 therapy.

W Den Otter·L Balemans·J J Battermann·M R Bernsen·J A Cadee·Z Dobrowolski·L A Everse·L Fiszer-Maliszewska·R Gavhumende·J W De Groot·K De Groot·W E Hennink·F W Hill·I Jurgenliemp-Schulz·W R Klein·J W Koten·R A Maas·P Steerenberg·R Stewart·M Zembala
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Abstract

Interleukin-2 (IL-2) is a powerful drug for treating cancer. However, it is only powerful if it is properly applied. That is, IL-2 should be applied at the tumor site, because at the transition of normal and malignant tissue are the tumor infiltrating cells. These should be activated by IL-2. Local application implies that IL-2 can be used in relatively low doses. It is becoming clear that even a single injection of IL-2 can cure cancer. IL-2 can also enhance the therapeutic effects of irradiation and Cisplatin. Locally applied IL-2 therapy is virtually non-toxic.

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AnimalsCarcinoma, Squamous CellCattleCisplatinCombined Modality TherapyDose-Response Relationship, DrugEye NeoplasmsHumansInjections, IntralesionalInterleukin-2LymphomaMammary Neoplasms, ExperimentalMast-Cell SarcomaMiceMice, Inbred DBANeoplasm TransplantationNeoplasmsTime FactorsTumor Cells, CulturedUrinary Bladder NeoplasmsJournal ArticleResearch Support, Non-U.S. Gov't

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W Den Otter, L Balemans, J J Battermann, M R Bernsen, J A Cadee, Z Dobrowolski, L A Everse, L Fiszer-Maliszewska, R Gavhumende, J W De Groot, K De Groot, W E Hennink, F W Hill, I Jurgenliemp-Schulz, W R Klein, J W Koten, R A Maas, P Steerenberg, R Stewart, M Zembala. 1999. Local low-dose IL-2 therapy.. https://pubmed.ncbi.nlm.nih.gov/10429975/

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