Source localization in an inhomogeneous physical thorax phantom.

Abstract

The influence of lung inhomogeneities on focal source localizations in electrocardiography (ECG) and magnetocardiography (MCG) is investigated. A realistically shaped physical thorax phantom with cylindrical lung inhomogeneities is used for electric and magnetic measurements. The lungs are modelled with a special ionic exchange membrane which allows different conductivity compartments without influencing the free ionic current flow. The dipolar current sources are composed of platinum wire and located at different depths and directions between the lung inhomogeneities. We localized the current dipoles with different boundary element method (BEM) models, based on electrical data and simultaneous electrical and magnetic data. Our results indicate the possibility of superadditive information gain by combining electrical and magnetic data for source reconstructions. We found a significant influence of the inhomogeneities on both the calculated source location and the calculated source strength. Mislocalizations of up to 16 mm and wrong dipole strengths of up to 52% were obtained when the lung inhomogeneities were not taken into account for source localization. Dipoles parallel to the lungs showed a larger localization error in depth than dipoles perpendicular to the lungs. We conclude that the incorporation of lung inhomogeneities will improve source localization accuracy in ECG and MCG.