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PubMed · 10849018

Gastrotonometry represents dramatic increase in PcO2 after acetazolamide administration.

K Taki·K Oogushi·K Tozuka
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Abstract

BACKGROUND: We sought to evaluate the parameters of CO2 transport during the administration of acetazolamide in order to assess the role of carbonic anhydrase in CO2 transport. MATERIALS AND METHODS: The partial pressure of carbon dioxide in tissue (PtCO2), arterial blood (PaCO2) and end-tidal gas (PETCO2) were monitored to study the correlation between PaCO2, PtCO2 and PETCO2 in spontaneously breathing healthy volunteers after the intravenous administration of acetazolamide 6 mg kg-1. RESULTS: At 60 min after the administration of acetazolamide, the PtCO2 peaked at more than 60 mmHg, and although it decreased by 90 min, it then remained stable above the baseline value. The PaCO2 did not change and the PETCO2 decreased significantly. The changes in PtCO2 were greater than those of either PaCO2 or PETCO2. The minute ventilation increased progressively throughout the study. CONCLUSIONS: We concluded that gastrotonometry represents a new method for monitoring the dramatic increase in PtCO2 induced by drugs such as acetazolamide clinically, and that it could be a warning against acetazolamide administration in severe patients without keeping a ventilation and circulation reserve.

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AcetazolamideAdultBlood PressureCarbon DioxideCarbonic Anhydrase InhibitorsCarbonic AnhydrasesGastric MucosaHeart RateHumansInjections, IntravenousMaleManometryOxygenPartial PressureRespirationClinical TrialJournal Article

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K Taki, K Oogushi, K Tozuka. 2000. Gastrotonometry represents dramatic increase in PcO2 after acetazolamide administration.. https://doi.org/10.1046/j.1365-2362.2000.00663.x

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