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Fugu: a compact vertebrate reference genome.

B Venkatesh·P Gilligan·S Brenner
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Abstract

At 400 Mb, the Japanese pufferfish, Fugu rubripes, has the smallest vertebrate genome but has a similar gene repertoire to other vertebrates. Its genes are densely packed with short intergenic and intronic sequences devoid of repetitive elements. It likely has a mutational bias towards DNA elimination and is probably close to a 'minimal' vertebrate genome. As such it is a useful reference genome for gene discovery and gene validation in other vertebrates. Its usefulness in the discovery of conserved regulatory elements has already been demonstrated. The Fugu genome sequence is a good complement to genetic studies in other vertebrates.

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B Venkatesh, P Gilligan, S Brenner. 2000-06-30. Fugu: a compact vertebrate reference genome.. https://doi.org/10.1016/s0014-5793(00)01659-8

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