[Evaluation of vascular endothelial function].

T Oshima; Y Higashi; R Ozono; Y Nakano; M Ishida; M Kambe; H Matsuura; G Kajiyama

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PubMed · 11051805

[Evaluation of vascular endothelial function].

T Oshima·Y Higashi·R Ozono·Y Nakano·M Ishida·M Kambe·H Matsuura·G Kajiyama

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Abstract

Endothelial function was evaluated in renal and forearm vessels from patients with essential hypertension. First, the increase in renal blood flow evaluated by the clearance of para-aminohippurate, serum c-GMP and urinary NOx during L-arginine infusion was significantly attenuated in essential hypertension. This attenuated endothelium-dependent vasodilation was improved by angiotensin converting enzyme inhibitor, but unchanged by calcium antagonist. Second, the increase in forearm blood flow evaluated by plethysmography during acetylcholine infusion or reactive hyperemia was attenuated in essential hypertension. This attenuation was abolished by NO synthesis inhibitor. Forearm endothelial function was improved by angiotensin converting enzyme inhibitor, daily aerobic exercise and body weight reduction by low calorie diet. In conclusion, endothelium-dependent vasodilation was attenuated in renal and forearm vasculature of essential hypertensives via reduction of NO synthesis. This attenuation can be improved by several treatments.

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Acetylcholine Angiotensin-Converting Enzyme Inhibitors Arginine Endothelium, Vascular Forearm Humans Hypertension Kidney Nitric Oxide Synthase Plethysmography English Abstract Journal Article Review

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T Oshima, Y Higashi, R Ozono, Y Nakano, M Ishida, M Kambe, H Matsuura, G Kajiyama. 2000. [Evaluation of vascular endothelial function].. https://pubmed.ncbi.nlm.nih.gov/11051805/

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