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PubMed · 1111369

Individual organ contributions to the decrease in whole-body Vo2 with isoflurane.

R A Theye·J D Michenfelder
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Abstract

The present study was designed to determine whether there were differebnces between the effects of isoflurane and halothane on canine whole-body Vo2 and myocardial, splanchnic, renal, and skelatal muscle Vo2's were determined at isoflurane concentrations equivilent to those used in a previous study with holothane. With increases in isoflurane, whole-body Vo2 decreased progressively. As with halothane, the major comdial Vo2 that was related to a reduction in cardiac output and arterial blood pressure; contributions from other organs were minor. No significant difference between the effects of isoflurane and halothane on whole-body or individual organ Vo2's was found. These finding support the view that anesthetic agents are no general metabolic depressants and that observed changed in whole-body Vo2 reflect the su-mated changes in individual argan Vo2's occasioned by an anesthetic-induced change in organ function and metabolic requirements.

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AnestheticsAnimalsBlood PressureDogsEthersHalothaneHeartHeart RateHeart VentriclesHydrocarbons, FluorinatedKidneyMusclesMyocardiumOxygen ConsumptionPressureRegional Blood FlowComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

R A Theye, J D Michenfelder. 1975. Individual organ contributions to the decrease in whole-body Vo2 with isoflurane.. https://doi.org/10.1097/00000542-197501000-00007

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