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Closed testing procedures for group sequential clinical trials with multiple endpoints.

D I Tang·N L Geller
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Abstract

A simple approach is given for conducting closed testing in clinical trials with multiple endpoints in which group sequential monitoring is planned. The approach allows a flexible stopping time; the earliest and latest stopping times are described. The paradigm is applicable both to clinical trials with multiple endpoints and to the one-sided multiple comparison problem of several treatments versus a control. The approach leads to enhancements of previous methods and suggestions for new methods. An example of a respiratory disease trial with four endpoints is given.

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BiometryClinical Trials as TopicCross-Over StudiesHumansRespiratory Tract DiseasesTime FactorsComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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D I Tang, N L Geller. 1999. Closed testing procedures for group sequential clinical trials with multiple endpoints.. https://doi.org/10.1111/j.0006-341x.1999.01188.x

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