[Pathomorphological changes in the kidneys in experimental hypothyroidism].

E I Gasparian

PubMed · 1144328

[Pathomorphological changes in the kidneys in experimental hypothyroidism].

Abstract

Morphohistochemical changes were studied in the kidneys of rats in experimental hypothyroidism. The latter was induced by subtotal thyroidectomy (observation periods--60 days), feeding of 6-methylthiouracil (observation periods--100 days), feeding of 6-methylthiouracil to thyroidectomized animals (observation periods--7 to 60 days). Animals of all the three groups displayed morphohistochemical signs of disturbance of acid and neutral polysaccharide metabolism in the vaso-stromal structures of the kidneys and also in the glomeruli. The degree of these changes depended directly on the extent and the duration of a hypothyroid condition. The changes described led to development of sclerosis. Among these changes attention was attracted to deposition of calcium salts in the epithelium, chiefly of the distal tubules.

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Animals Calcinosis Hypothyroidism Kidney Kidney Glomerulus Kidney Tubules, Distal Male Methylthiouracil Polysaccharides Rats Thyroidectomy English Abstract Journal Article

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E I Gasparian. [Pathomorphological changes in the kidneys in experimental hypothyroidism].. https://pubmed.ncbi.nlm.nih.gov/1144328/

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