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PubMed · 1151682

Dissolution profile in relation to initial particle distribution.

P V Pedersen·K F Brown
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Abstract

A general equation was derived describing the complete and exact dissolution profile of powders under sink conditions. It is applicable to powders having any initial particle-size distribution, with particles dissolving according to any explicit equation. It was applied to develop an equation for the dissolution of log-normal powders that is more generally applicable than previous approaches. The effect of change in initial particle-size distribution parameters on the dissolution profile is illustrated.

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P V Pedersen, K F Brown. 1975. Dissolution profile in relation to initial particle distribution.. https://doi.org/10.1002/jps.2600640713

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