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MPGN type I induced by granulocyte colony stimulating factor.

Daniella Magen·Hana Mandel·Moshe Berant·Ofer Ben-Izhak·Israel Zelikovic
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Abstract

We report a girl with severe congenital neutropenia who has received long-term granulocyte-colony stimulating factor (G-CSF) therapy and has developed macroscopic hematuria, proteinuria, and decreased renal function associated with biopsy-proven membranoproliferative glomerulonephritis (MPGN) type I. Temporary discontinuation of G-CSF therapy as well as the use of glycosylated G-CSF has resulted in improvement in renal manifestations. We postulate that the MPGN was G-CSF-induced. Long-term G-CSF therapy should be used with great caution and close surveillance of kidney function.

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Adjuvants, ImmunologicAdolescentDrug Administration ScheduleFemaleGlomerulonephritis, MembranoproliferativeGranulocyte Colony-Stimulating FactorHumansLenograstimNeutropeniaRecombinant ProteinsRetreatmentCase ReportsJournal Article

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Daniella Magen, Hana Mandel, Moshe Berant, Ofer Ben-Izhak, Israel Zelikovic. 2002. MPGN type I induced by granulocyte colony stimulating factor.. https://doi.org/10.1007/s00467-002-0847-9

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