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Conserved function for embryonic nodal cilia.

Jeffrey J Essner·Kyle J Vogan·Molly K Wagner·Clifford J Tabin·H Joseph Yost·Martina Brueckner
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Abstract

How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.

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AnimalsAxonemal DyneinsBody PatterningChick EmbryoCiliaConserved SequenceDyneinsEmbryo, MammalianEmbryo, NonmammalianGastrulaGene Expression ProfilingGene Expression Regulation, DevelopmentalMiceOrganizers, EmbryonicSignal TransductionVertebratesXenopusZebrafishZebrafish ProteinsJournal Article

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Jeffrey J Essner, Kyle J Vogan, Molly K Wagner, Clifford J Tabin, H Joseph Yost, Martina Brueckner. 2002-07-04. Conserved function for embryonic nodal cilia.. https://doi.org/10.1038/418037a

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