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PubMed · 12285510

[Ethnodemography: problems and priorities].

B Mizov
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Abstract

"The author [suggests] that Bulgarian ethnodemography should study the ethnic 'cross section' of demographic processes on three levels: first, in the European context; second, on the regional (Balkan) level, and third, on the national (including subnational) level." The focus is on mapping the ethnic groups of Bulgaria. (SUMMARY IN ENG)

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BulgariaCultureDemographyDeveloped CountriesEthnicityEuropeEurope, EasternGeographyMaps as TopicPopulationPopulation CharacteristicsResearchComparative StudiesCultural BackgroundDemographic FactorsEastern EuropeEthnic GroupsGeographic FactorsMapsResearch MethodologySpatial DistributionStudiesComparative StudyJournal Article

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B Mizov. 1992. [Ethnodemography: problems and priorities].. https://pubmed.ncbi.nlm.nih.gov/12285510/

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It has been hypothesized that insulin-like growth factors (IGFs) and components of the growth-hormone (GH)-IGF axis may underlie reported associations of poor fetal and childhood growth with schizophrenia. We have investigated the association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter-marker distance of approximately 2-3 kb. We also examined associations with four common functional polymorphisms of genes involved in aspects of the GH-IGF system--the IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), growth hormone (GH1), and IGF binding protein-3 (IGFBP3). The study was based on an analysis of pooled DNA samples from 648 UK and Irish cases of schizophrenia and 712 blood donor controls and of 297 Bulgarian parent offspring trios. In replicated pool analyses, none of the 16 SNPs in IGF1 nor the 4 key SNPs in the other growth pathway genes were associated with schizophrenia. SNP coverage of IGF1 was extensive, so our findings do not support a major role for IGF-I in the aetiology of schizophrenia.

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