PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 12341627

[Regional differences in urbanization].

B Csatari·J Toth
View original source ↗Export metadata ↓

Abstract

"Relying on population data of Hungary's town network, the authors review temporal and regional differences in urbanization. They trace back the data of 109 towns...[from] 1985 to the first official census of population, then they analyse by means of rank correlation the lags appearing in the concentration rate of urban population.... The authors think that urbanization of small towns might be the key element in the spatial and structural extension of urbanization. In the authors' opinion the lasting regional differences of urbanization determine also the centres of gravity of future development." (SUMMARY IN ENG AND RUS)

Explore related subjects

DemographyDeveloped CountriesEuropeEurope, EasternGeographyHungaryPopulationPopulation DensityPopulation DynamicsTime FactorsUrban PopulationUrbanizationDemographic FactorsEastern EuropeGeographic FactorsSpatial Distribution--changesUrban Spatial DistributionEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

B Csatari, J Toth. 1988. [Regional differences in urbanization].. https://pubmed.ncbi.nlm.nih.gov/12341627/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2003

Demography, recombination hotspot intensity, and the block structure of linkage disequilibrium.

BACKGROUND: Effective gene mapping based on genetic association data will require detailed knowledge of patterns of linkage disequilibrium (LD) in human populations. It has been recently suggested that linkage disequilibrium in humans may be organized in a block-like structure, with islands of high LD separated by regions of rapid breakdown of LD due to recombination hotspots. The experimental data to date, however, are limited, and fundamental questions remain about the implications of recombination rate heterogeneity. Here, we use computer simulations to evaluate how such heterogeneity influences patterns of LD, and we develop formal criteria to assess whether the patterns are functionally block like in the context of association mapping. RESULTS: Our analyses suggest that, even in models of extreme recombination rate heterogeneity, some human populations will have a functionally block-like structure to the pattern of LD, but others will not, depending on their precise demographic histories. In fact, for many models, we find that, following an LD-generating event, populations may move through discrete phases that can be functionally described as pre-block, block, and post-block. An analysis of observed and expected patterns of LD surrounding hotspots within the MHC Class II region confirms these theoretical expectations. CONCLUSIONS: Even if highly punctuated patterns of recombination are the rule, patterns of LD are still likely to show differences among populations and among genomic regions that are of practical importance in the design of genetic association studies. The notion that the average extent of LD is a useful concept for the design of association studies must be abandoned in light of the experimental and theoretical evidence.

Demography↗
PubMed2003

Hematopoietic stem cell transplantation for hematological malignancies in Europe.

Hematopoietic stem cell transplants (HSCTs) are considered the best treatment option for many hematological malignancies, and transplant numbers have increased five-fold during the last decade. Only a few controlled prospective studies are available, and different opinions prevail. Data from 118 167 HSCT (36% allogeneic, 64% autologous) collected within the EBMT activity survey from 1990 to 2001 were used to assess trends over time, transplant rates and coefficient of variation (CV) of transplant rates among European countries for acute myeloid leukemia (AML; 18.5%), acute lymphocytic leukemia (ALL; 12%), chronic myeloid leukemia (CML; 11.5%), myelodysplastic syndromes (MDS; 3%), lymphoproliferative disorders (LPS; 36.3%) and multiple myeloma (MM; 18.7%). Transplant rates increased in all countries and for all indications from 1990 to 2001 from 1.7-fold (CML) to 24.8-fold (MM). Transplant rates have declined for CML since 1999. Autologous HSCT are the preferred choice for LPS and MM, allogeneic HSCT for ALL and myeloid malignancies. CVs of less than 50% suggest consensus for allogeneic HSCT in AML, ALL, CML, MDS and NHL, for autologous HSCT in LPS and MM. These data give an overview of the current status of HSCT for hematological malignancies in Europe and provide objective information for health-care providers and patient counselling.

Demography↗