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Vancomycin encapsulation in biodegradable poly(epsilon-caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility.

A-M Le Ray·S Chiffoleau·P Iooss·G Grimandi·A Gouyette·G Daculsi·C Merle
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Abstract

Vancomycin encapsulation in biodegradable poly(epsilon-caprolactone) microparticles (200 microm mean diameter) was most efficient with a simple emulsion technique that dispersed 122.5 mg/g of polymer. Scanning electron micrographs showed smooth or pitted particles. Dissolution studies were correlated with microparticle morphology, indicating higher release with pitted particles when vancomycin was encapsulated in a dissolved state. The cytocompatibility of these poly(epsilon-caprolactone) microparticles was demonstrated by a direct contact cytotoxic assay. This material can be considered as an efficient drug delivery system for bone implantation.

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Absorbable ImplantsAnimalsAnti-Bacterial AgentsBiocompatible MaterialsBone SubstitutesCaproatesCell LineDrug Delivery SystemsFibroblastsKineticsLactonesMiceMicroscopy, Electron, ScanningSpectrophotometryTime FactorsVancomycinJournal Article

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A-M Le Ray, S Chiffoleau, P Iooss, G Grimandi, A Gouyette, G Daculsi, C Merle. 2003. Vancomycin encapsulation in biodegradable poly(epsilon-caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility.. https://doi.org/10.1016/s0142-9612(02)00357-5

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