Parameter estimation in a crossbridge muscle model.

David C Lin; T Richard Nichols

doi:10.1115/1.1537262

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Parameter estimation in a crossbridge muscle model.

David C Lin·T Richard Nichols

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Abstract

Models of muscle crossbridge dynamics have great potential for understanding muscle contraction and having a wide range of application. However, the estimation of many model parameters, most of which are difficult to measure, limits their applicability. This study developed a method of estimating parameters in the Distribution Moment crossbridge model from measurements of force-length and force-velocity relationships in cat soleus single muscle fibers. Analysis of the parameter estimates showed that the detachment rate parameters had more uncertainty than the attachment rate parameter, which could reflect physiological variations in the contractile protein content and in the response of muscle to lengthenings.

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Animals Ankle Cats Computer Simulation Elasticity In Vitro Techniques Models, Biological Motion Muscle Contraction Muscle Fibers, Skeletal Muscle, Skeletal Physical Stimulation Stress, Mechanical Comparative Study Evaluation Study Journal Article Research Support, U.S. Gov't, P.H.S.Validation Study

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David C Lin, T Richard Nichols. 2003. Parameter estimation in a crossbridge muscle model.. https://doi.org/10.1115/1.1537262

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