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A deoxyribozyme-based molecular automaton.

Milan N Stojanovic·Darko Stefanovic
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Abstract

We describe a molecular automaton, called MAYA, which encodes a version of the game of tic-tac-toe and interactively competes against a human opponent. The automaton is a Boolean network of deoxyribozymes that incorporates 23 molecular-scale logic gates and one constitutively active deoxyribozyme arrayed in nine wells (3x3) corresponding to the game board. To make a move, MAYA carries out an analysis of the input oligonucleotide keyed to a particular move by the human opponent and indicates a move by fluorescence signaling in a response well. The cycle of human player input and automaton response continues until there is a draw or a victory for the automaton. The automaton cannot be defeated because it implements a perfect strategy.

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AlgorithmsArtificial IntelligenceBase SequenceCompetitive BehaviorComputers, MolecularComputing MethodologiesCyberneticsDNA, CatalyticHumansInformation Storage and RetrievalLogicMacromolecular SubstancesMolecular Sequence DataComparative StudyEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Validation Study

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Milan N Stojanovic, Darko Stefanovic. 2003-08-17. A deoxyribozyme-based molecular automaton.. https://doi.org/10.1038/nbt862

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