Ondansetron-induced multifocal encephalopathy.

Matthew J Ritter; Brent P Goodman; Juraj Sprung; Eelco F M Wijdicks

doi:10.4065/78.9.1150

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Ondansetron-induced multifocal encephalopathy.

Matthew J Ritter·Brent P Goodman·Juraj Sprung·Eelco F M Wijdicks

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Abstract

We treated a patient who developed transient multifocal encephalopathy with extrapyramidal symptoms (oromandibular dystonia, oculogyric crisis, and limb dystonia) in temporal proximity to ondansetron administration on emergence from general anesthesia. No other medications known to cause extrapyramidal reactions were administered. Although these symptoms resolved fully, the presentation was dramatic and resembled the symptoms of structural brain injury. Ondansetron is used frequently as an antiemetic agent in many clinical settings and is not limited to surgical patients. Therefore, the entire medical community should be cognizant of this potential adverse reaction.

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Antiemetics Brain Diseases Dystonia Female Hand Humans Mandible Middle Aged Mouth Ocular Motility Disorders Ondansetron Postoperative Nausea and Vomiting Case Reports Journal Article

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Matthew J Ritter, Brent P Goodman, Juraj Sprung, Eelco F M Wijdicks. 2003. Ondansetron-induced multifocal encephalopathy.. https://doi.org/10.4065/78.9.1150

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