PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 13498174

Effects in dogs of decrease in glomerular filtration rate on cation excretion during intravenous administration of unreabsorbable anions.

H D Lauson·D D Thompson
View original source ↗Export metadata ↓

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

Administration, IntravenousAnimalsAnionsCationsDogsGlomerular Filtration RateKidneyKIDNEYS/physiologyJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H D Lauson, D D Thompson. 1958. Effects in dogs of decrease in glomerular filtration rate on cation excretion during intravenous administration of unreabsorbable anions.. https://doi.org/10.1152/ajplegacy.1957.192.1.198

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2021

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset.

Genetic intervention is increasingly being explored as a therapeutic option for debilitating disorders of the central nervous system. The safety and efficacy of gene therapies rely upon expressing a transgene in affected cells while minimizing off-target expression. Here we show organ-specific targeting of adeno-associated virus (AAV) capsids after intravenous delivery, which we achieved by employing a Cre-transgenic-based screening platform and sequential engineering of AAV-PHP.eB between the surface-exposed AA452 and AA460 of VP3. From this selection, we identified capsid variants that were enriched in the brain and targeted away from the liver in C57BL/6J mice. This tropism extends to marmoset (Callithrix jacchus), enabling robust, non-invasive gene delivery to the marmoset brain after intravenous administration. Notably, the capsids identified result in distinct transgene expression profiles within the brain, with one exhibiting high specificity to neurons. The ability to cross the blood-brain barrier with neuronal specificity in rodents and non-human primates enables new avenues for basic research and therapeutic possibilities unattainable with naturally occurring serotypes.

Administration, Intravenous↗