PubMed · 14377120
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A AUBIN, ESTENNE. 1954. Stylalgia.. https://pubmed.ncbi.nlm.nih.gov/14377120/
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BACKGROUND: Cephalometry is useful as a screening test for anatomical abnormalities in patients with obstructive sleep apnoea syndrome (OSAS). OBJECTIVE: To evaluate comprehensively the cephalometric features of children with OSAS, with or without adenotonsillar hypertrophy, and to elucidate the relationship between cephalometric variables and apnoea-hypopnoea index (AHI) severity. MATERIALS AND METHODS: The study population consisted of 39 children, aged 4-12 years, with OSAS. Cephalometry was analysed using 11 measurements of the bony structures, their relationships and the size of the airways. Additionally, adenoid and tonsillar hypertrophy were graded. RESULTS: Cranial base angles (BaSN and BaSPNS) were found to correlate with increasing levels of AHI scores (P<0.001). Protrusion of the maxilla (SNA) and mandible (SNB) did not correlate with AHI scores (P>0.05). The length of the mandibular plane (GnGo) and the minimal posterior airway space (MPAS) were inversely correlated with AHI scores (P<0.001). There was positive correlation between MPAS and GnGo (r=0.740, P<0.001), and negative correlation between MPAS and gonial angle (ArGoGn) (r=-0.541, P<0.001). There was significant correlation between cephalometric data and adenotonsillar hypertrophy concerning BaSN, BaSPNS, ArGoGn, GnGoH, BaN-GnGo, MPAS, GnGO and MPH (P<0.001). CONCLUSIONS: There is significant correlation between cephalometric data and AHI score severity in children with OSAS. Adenotonsillar hypertrophy affects the cephalometric measurements adversely. The study clearly mandates the institution of early and effective therapy of adenotonsillar hypertrophy in children with OSAS.
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OBJECTIVE: In previous studies of the adenoid surface secretion we revealed the presence of activated T cells, granulocytes engaged in phagocytosis and immunocytes that produce IgG, IgA and IgM. In the present study the objective was to assess the ability of these immunocytes to produce antibodies directed at S. pneumoniae. METHOD: Nine children subjected to adenoidectomy due to adenoid hypertrophy, secretory otitis media or recurrent otitis media were enrolled in the study. Samples of adenoid surface secretion were obtained by an imprint method and for comparison samples of adenoid tissue and peripheral blood were also obtained as well as a nasopharyngeal culture. Double-colour enzyme-linked immunospot (ELISPOT) assays were performed to detect total and pneumococci-specific IgG- and IgA-antibody secreting cells (ASC). In the adenoid tissue, the presence of H. influenzae type b specific ASC was also examined. RESULTS: ASC were present in all nine samples of adenoid surface secretion with a dominance of IgG-ASC as compared to IgA-ASC. The proportion of ASC relative to the total number of lymphocytes was always greater in the secretion than in the corresponding adenoid tissue. The adenoid surface secretion samples from three of nine children contained IgG-ASC directed against S. pneumoniae. IgG-ASC directed against S. pneumoniae were detected in six of eight adenoids and IgA-ASC directed against S. pneumoniae were detected in two of eight adenoids. IgA-ASC directed against H. influenzae type b (Hib) were detected in one of seven adenoids. CONCLUSION: The immunocytes in the adenoid surface secretion and the adenoid tissue itself hold the property to produce antibodies specific for known pathogens of the upper airways. These ASC are probably engaged in the immunologic defence of the nasopharyngeal mucosa and further studies are therefore called upon.