PubMed · 14716173
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Ronn E Tanel. 2004. ECGs in the ED.. https://doi.org/10.1097/01.pec.0000111161.10914.95
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The aim of the study was to define more exactly correlations between circulatory disturbances in the common carotid artery (CCA) basin, and hemodynamic disturbances and structural myocardial remodeling in patients suffering from arterial hypertension (AH) and cerebral atherosclerosis. The subjects were 83 patients evaluated by means of carotid arterial Doppler ultrasonography and echoCG; the variables of central homodynamic were measured as well. The study revealed that patients with AH and moderate CCA stenosis displayed hyperkinetic hemodynamic type more often than patients with severe CCA stenosis, of whom hypodynamic hemodynamic type was more typical. Left ventricular (LV) myocardial remodeling was more frequent in the latter group of patients; asymmetric LV hypertrophy prevailed. The study shows that the process of remodeling, caused by dissociation between central and regional hemodynamics, develops together with the progress of atherosclerotic arterial lesion.
Clinical phenotype of hypertrophic cardiomyopathy exhibits significant inter- and intra-familial heterogeneities. To test if MYBPC3 polymorphism could modify the expression of cardiac hypertrophy, 226 patients with hypertrophic cardiomyopathy and 226 age- and sex-matched controls were recruited according to the diagnostic criteria of WHO. Genotyping was completed by using PCR, restrictive enzyme digestion, and sequencing. Three polymorphisms of MYBPC3 were studied, only the GG genotype at 18443 in exon 30 associated with thicker left ventricular wall (25.2+/-5.9 mm) in patient group, not the AA and AG genotypes (19.0+/-5.0mm, P<0.001). After multiple regression analysis for adjustment of age and sex, the association remained. No difference was found in the genotype distribution between control and patients. Our results point out that GG genotype of MYBPC3 might be a genetic risk factor for the expression of cardiac hypertrophic phenotype in the patients with hypertrophic cardiomyopathy.