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Quantitative analysis of pulmonary perfusion using time-resolved parallel 3D MRI - initial results.

C Fink·F Risse·R Buhmann·S Ley·F J Meyer·C Plathow·M Puderbach·H-U Kauczor
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Abstract

PURPOSE: To assess the use of time-resolved parallel 3D MRI for a quantitative analysis of pulmonary perfusion in patients with cardiopulmonary disease. MATERIALS AND METHODS: Eight patients with pulmonary embolism or pulmonary hypertension were examined with a time-resolved 3D gradient echo pulse sequence with parallel imaging techniques (FLASH 3D, TE/TR: 0.8/1.9 ms; flip angle: 40 degrees; GRAPPA). A quantitative perfusion analysis based on indicator dilution theory was performed using a dedicated software. RESULTS: Patients with pulmonary embolism or chronic thromboembolic pulmonary hypertension revealed characteristic wedge-shaped perfusion defects at perfusion MRI. They were characterized by a decreased pulmonary blood flow (PBF) and pulmonary blood volume (PBV) and increased mean transit time (MTT). Patients with primary pulmonary hypertension or Eisenmenger syndrome showed a more homogeneous perfusion pattern. The mean MTT of all patients was 3.3 - 4.7 s. The mean PBF and PBV showed a broader interindividual variation (PBF: 104 - 322 ml/100 ml/min; PBV: 8 - 21 ml/100 ml). CONCLUSION: Time-resolved parallel 3D MRI allows at least a semi-quantitative assessment of lung perfusion. Future studies will have to assess the clinical value of this quantitative information for the diagnosis and management of cardiopulmonary disease.

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Acute DiseaseAdultAgedChronic DiseaseEisenmenger ComplexFemaleHumansHypertension, PulmonaryImaging, Three-DimensionalLungMagnetic Resonance ImagingMaleMiddle AgedModels, BiologicalPulmonary CirculationPulmonary EmbolismComparative StudyEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov't

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C Fink, F Risse, R Buhmann, S Ley, F J Meyer, C Plathow, M Puderbach, H-U Kauczor. 2004. Quantitative analysis of pulmonary perfusion using time-resolved parallel 3D MRI - initial results.. https://doi.org/10.1055/s-2004-817624

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