PubMed · 14983532
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Daniel McGinn. 2004-02-16. Tracking safety.. https://pubmed.ncbi.nlm.nih.gov/14983532/
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Ninety-three human cadaver tests are used in the development of thoracic injury risk functions with consideration of age and restraint condition. Linear logistic regression models are developed with the set of potential predictors including the maximum chest deflection, the age of the cadaver at death, gender, and the loading condition on the anterior thorax: blunt hub (41 tests), seat belt (26 tests), air bag (12 tests), and combined belt-and-bag (14 tests). Predicted outcomes were the probability of any rib fractures (onset of injury) and the probability of greater than six rib fractures (severe injury). The analysis shows that the injury risk function was not dependent on the loading condition, but was strongly dependent on age. A significant injury risk model with good ability to discriminate injury from non-injury tests (P < 0.0001, chi-square = 21.49, area under receiver operator characteristic curve (ROC) = 0.867, Kruskal's Gamma = 0.732) is presented using only maximum chest deflection and cadaver age as predictors of injury risk. The 50% risk of any rib fractures is found to occur at 35% chest deflection for a 30-year-old, but at 13% deflection for a 70-year-old. The 50% risk of severe injury is shown to occur at 33% chest deflection for a 70-year-old, but at 43% for a 30-year-old.
BACKGROUND: The purpose of this study was to assess interregional brain activity covariations during traumatic script-driven imagery in subjects with posttraumatic stress disorder (PTSD). METHODS: Functional magnetic resonance imaging and functional connectivity analyses were used to assess interregional brain activity covariations during script-driven imagery in PTSD subjects with a dissociative response, PTSD subjects with a flashback response, and healthy control subjects. RESULTS: Significant between-group differences in functional connectivity were found. Comparing dissociated PTSD patients and control subjects' connectivity maps in the left ventrolateral thalamus (VLT) [-14, -16, 4] revealed that control subjects had higher covariations between activations in VLT and in the left superior frontal gyrus (Brodmann's area [BA] 10), right parahippocampal gyrus (BA 30), and right superior occipital gyrus (BA 19, 39), whereas greater covariation with VLT in dissociated PTSD subjects occurred in the right insula (BA 13, 34), left parietal lobe (BA 7), right middle frontal gyrus (BA 8), superior temporal gyrus (BA 38, 34), and right cuneus (BA 19). Comparing dissociated PTSD and flashback PTSD connectivity maps in the right cingulate gyrus [3, 16, 30] revealed that dissociated PTSD subjects had higher covariations between activations in this region and the left inferior frontal gyrus (BA 47). CONCLUSIONS: Greater activation of neural networks involved in representing bodily states was seen in dissociated PTSD subjects than in non-PTSD control subjects. These findings might illuminate the mechanisms underlying distorted body perceptions often observed clinically during dissociative episodes.
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