[Non-erosive GERD].

Michio Hongo; Daisaku Tamura

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PubMed · 15344552

[Non-erosive GERD].

Michio Hongo·Daisaku Tamura

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Abstract

Non-erosive reflux disease (NERD) is defined as those who have typical reflux symptoms without evidence of erosive changes in their lower esophageal mucosa. Symptoms should occur more than twice a week, and esophageal mucosa should be free from erosion. However, the differentiation from normal might be difficult because of the ambiguous definition. Pathophysiological mechanism on heartburn is not simply acidic stimuli to esophageal mucosa, but also esophageal distention, hypersensitive esophagus and/or exaggerate perception. NERD is not a simply milder form of reflux disease, because they have poor response to pharmacotherapy. Based on such evidence, newer concept for NERD is required.

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Enzyme Inhibitors Esophagus Gastroesophageal Reflux Heartburn Humans Hydrogen-Ion Concentration Life Style Monitoring, Physiologic Proton Pump Inhibitors English Abstract Journal Article Review

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Michio Hongo, Daisaku Tamura. 2004. [Non-erosive GERD].. https://pubmed.ncbi.nlm.nih.gov/15344552/

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