Endothelium-derived hyperpolarizing factor (EDHF).

H Suzuki; G Chen; Y Yamamoto

doi:10.1253/jcj.56.170

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Endothelium-derived hyperpolarizing factor (EDHF).

H Suzuki·G Chen·Y Yamamoto

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Abstract

In vascular tissues, many types of stimulants which release endothelium-derived relaxing factor (EDRF) hyperpolarized the smooth muscle membrane in an endothelium-dependent manner. The hyperpolarizations were resistant to inhibitors of the actions of EDRF, thereby suggesting that they were elicited by an unidentified substance called endothelium-derived hyperpolarizing factor (EDHF). The EDHF induced hyperpolarization was produced by an increase in K(+)-permeability of the membrane, and was one of the factors to induce endothelium-dependent vasodilations. Release of EDHF required an increase in endothelial Ca2+, due either to release of Ca2+ from intracellular storage or to its influx from the external media.

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Animals Biological Factors Calcium Cell Membrane Permeability Dogs Electrophysiology Endothelium Guinea Pigs Humans Muscle Relaxation Muscle, Smooth, Vascular Potassium Journal Article Review

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H Suzuki, G Chen, Y Yamamoto. 1992. Endothelium-derived hyperpolarizing factor (EDHF).. https://doi.org/10.1253/jcj.56.170

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