Deoxyribozyme-based ligase logic gates and their initial circuits.

Milan N Stojanovic; Stanka Semova; Dmitry Kolpashchikov; Joanne Macdonald; Clint Morgan; Darko Stefanovic

doi:10.1021/ja043003a

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Deoxyribozyme-based ligase logic gates and their initial circuits.

Milan N Stojanovic·Stanka Semova·Dmitry Kolpashchikov·Joanne Macdonald·Clint Morgan·Darko Stefanovic

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Abstract

A complete set (YES, NOT, AND, and ANDNOT) of molecular scale logic gates based on ligase deoxyribozymes was constructed. The activity of these gates was visualized through the formation of cascades with downstream phosphodieseterase YES gates, which performed fluorogenic cleavage.

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Base Sequence Catalysis DNA Ligases DNA, Catalytic Logic Molecular Sequence Data Oligonucleotides Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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Milan N Stojanovic, Stanka Semova, Dmitry Kolpashchikov, Joanne Macdonald, Clint Morgan, Darko Stefanovic. 2005-05-18. Deoxyribozyme-based ligase logic gates and their initial circuits.. https://doi.org/10.1021/ja043003a

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