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PubMed · 16076432

Using silver nanoparticle to enhance current response of biosensor.

Xiangling Ren·Xianwei Meng·Dong Chen·Fangqiong Tang·Jun Jiao
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Abstract

In this paper, we present a simple procedure to increase the sensitivity of a glucose biosensor. The feasibility of an amperometric glucose biosensor based on immobilization of glucose oxidase (GOx) in silver (Ag) sol was investigated for the first time. GOx was simply mixed with Ag nanoparticles and cross-linked with a polyvinyl butyral (PVB) medium by glutaraldehyde. Then a platinum electrode was coated with the mixed solution. The effects of the amount of the Ag particles used, with respect to the current response for enzyme electrodes, were studied. A set of experimental results indicate that the current response for the enzyme electrode containing hydrophobic Ag sol increased from 0.531 to 31.17 microA in the solution of 10 mmol/L beta-D glucose. The time reaching the steady-state current response reduced from 60 to 20s, three times less than those without Ag particles involved.

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Biosensing TechniquesCoated Materials, BiocompatibleElectrochemistryEnzymes, ImmobilizedEquipment DesignEquipment Failure AnalysisGlucoseGlucose OxidaseNanostructuresParticle SizeReproducibility of ResultsSensitivity and SpecificitySilverSurface PropertiesComparative StudyEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Xiangling Ren, Xianwei Meng, Dong Chen, Fangqiong Tang, Jun Jiao. 2004-12-22. Using silver nanoparticle to enhance current response of biosensor.. https://doi.org/10.1016/j.bios.2004.08.052

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