Metastatic osteosarcoma.

Najat C Daw; Catherine A Billups; Carlos Rodriguez-Galindo; M Beth McCarville; Bhaskar N Rao; Alvida M Cain; Jesse J Jenkins; Michael D Neel; William H Meyer

doi:10.1002/cncr.21626

PubMed · 16353204

Metastatic osteosarcoma.

Najat C Daw·Catherine A Billups·Carlos Rodriguez-Galindo·M Beth McCarville·Bhaskar N Rao·Alvida M Cain·Jesse J Jenkins·Michael D Neel·William H Meyer

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Abstract

BACKGROUND: The outcome of patients with metastatic osteosarcoma treated in two consecutive trials from 1986 to 1997 was analyzed to evaluate the efficacy of carboplatin-based multiagent chemotherapy and to identify prognostic factors. The initial study (OS-86) used ifosfamide, cisplatin, doxorubicin, and high-dose methotrexate, and the subsequent study (OS-91) used the same agents at similar doses, but carboplatin was substituted for cisplatin. METHODS: Twelve patients (median age, 15.1 yrs) were treated in OS-86 for osteosarcoma metastatic to the lung only (11 patients) or bone only (1 patient), and 17 patients (median age, 15.1 yrs) were treated in OS-91 for osteosarcoma metastatic to the lung only (12 patients), bone only (2 patients), lung and bone (2 patients), or other site (1 patient). RESULTS: Patients with metastatic disease enrolled in OS-86 and those with metastatic disease enrolled in OS-91 did not differ in terms of demographic features, histologic subtype, site of primary tumor, or site of metastases. There was a difference in survival according to treatment protocol (P = 0.054). All survivors (four of whom were enrolled in OS-86 and one of whom was enrolled in OS-91) had lung metastases only. Five-year survival estimates for patients with lung metastases only were 45.5 +/- 13.7% (OS-86) and 8.3 +/- 5.6% (OS-91) (P = 0.084). Unilateral lung metastases (P = 0.006), no more than three lung nodules (P = 0.014), and surgical remission (P = 0.001) were associated with improved survival probability. CONCLUSIONS: The poor outcome of patients with metastatic osteosarcoma treated in OS-91 justifies the use of cisplatin with its associated toxicity in patients with high-risk disease.

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Najat C Daw, Catherine A Billups, Carlos Rodriguez-Galindo, M Beth McCarville, Bhaskar N Rao, Alvida M Cain, Jesse J Jenkins, Michael D Neel, William H Meyer. 2006-01-15. Metastatic osteosarcoma.. https://doi.org/10.1002/cncr.21626

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